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The Use and Effectiveness of Triple Multiplex System for Coding Region Single Nucleotide Polymorphism in Mitochondrial DNA Typing of Archaeologically Obtained Human Skeletons from Premodern Joseon Tombs of Korea

Title
The Use and Effectiveness of Triple Multiplex System for Coding Region Single Nucleotide Polymorphism in Mitochondrial DNA Typing of Archaeologically Obtained Human Skeletons from Premodern Joseon Tombs of Korea
Authors
Oh, Chang SeokLee, Soong DeokKim, Yi-SukShin, Dong Hoon
Ewha Authors
김이석
SCOPUS Author ID
김이석scopus
Issue Date
2015
Journal Title
BIOMED RESEARCH INTERNATIONAL
ISSN
2314-6133JCR Link2314-6141JCR Link
Publisher
HINDAWI PUBLISHING CORPORATION
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions SNPs could be also applicable to ancient samples from East Asia as the complementation for sequence analysis of mtDNA control region. By the study on Joseon skeleton samples, we know that mtDNA haplogroup determined by coding region SNP markers successfully falls within the same haplogroup that sequence analysis on control region can assign. Considering that ancient samples in previous studies make no small number of errors in control region mtDNA sequencing, coding region SNP analysis can be used as good complimentary to the conventional haplogroup determination, especially of archaeological human bone samples buried underground over long periods.
DOI
10.1155/2015/850648
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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