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Nosocomial exposure to active pulmonary tuberculosis in a neonatal intensive care unit

Title
Nosocomial exposure to active pulmonary tuberculosis in a neonatal intensive care unit
Authors
Ahn, Jong GyunKim, Dong SooKim, Ki Hwan
Ewha Authors
안종균
SCOPUS Author ID
안종균scopus
Issue Date
2015
Journal Title
AMERICAN JOURNAL OF INFECTION CONTROL
ISSN
0196-6553JCR Link1527-3296JCR Link
Citation
vol. 43, no. 12, pp. 1292 - 1295
Keywords
Pulmonary tuberculosisPostexposure prophylaxisChemoprophylaxisNeonatal intensive care unit
Publisher
MOSBY-ELSEVIER
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Nosocomial transmission of tuberculosis (TB) in a neonatal intensive care unit (NICU) is a recognized risk. We investigated TB transmission to neonates and health care workers (HCWs) exposed to a nurse with active TB in a NICU. Methods: A NICU nurse in a tertiary referral hospital in Seoul, Korea, developed pulmonary TB. The investigation included 108 infants and 75 HCWs. Tuberculin skin test (TST) and chest radiograph were performed at baseline. Isoniazid prophylaxis was started in neonates. After 3 months of prophylaxis, infants underwent repeat TST and chest radiograph. HCWs underwent a second TST after 3 months. Results: Baseline chest radiographs were negative in infants and HCWs. Four (3.7%) of 108 infants screened had a positive TST, including 2 conversions, and received isoniazid for 6-9 months. Among the 59 HCWs screened, 27 (45.8%) had an initial positive TST result, and 6 (10.2%) had a positive TST result at 3 months. Four of the 6 HCWs with TST conversions received isoniazid treatment for 9 months. In the 2-year period after exposure, none of the exposed infants or HCWs developed active TB. Conclusion: In this investigation, 4 (3.7%) of 108 infants exposed to a nurse with active TB developed latent TB infection. They were given isoniazid therapy without any adverse events and did not progress to TB disease in the 2 years after exposure. Copyright (C) 2015 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
DOI
10.1016/j.ajic.2015.07.020
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의료원 > 의료원 > Journal papers
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