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Demineralized deciduous tooth as a source of bone graft material: its biological and physicochemical characteristics

Title
Demineralized deciduous tooth as a source of bone graft material: its biological and physicochemical characteristics
Authors
Park, MiraeMah, Yon-JooKim, David-HyungjinKim, Eun-SukPark, Eun-Jin
Ewha Authors
박은진마연주
SCOPUS Author ID
박은진scopus; 마연주scopus
Issue Date
2015
Journal Title
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
ISSN
2212-4403JCR Link1528-395XJCR Link
Citation
vol. 120, no. 3, pp. 307 - 314
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective. To examine structural and physicochemical characteristics of demineralized deciduous tooth powder (DDTP) in relation to demineralization time and to present potential of using DDTP as a bone graft material. Study design. For structural and physicochemical analysis, scanning electron microscopy, inductively coupled plasma spectrometry, energy-dispersive X-ray analysis, X-ray diffraction analysis, differential scanning calorimetry, and Brunauer-Emmett-Teller surface area analysis were performed. In in vivo experiments, DDTP was grafted in 20 Sprague-Dawley rats' calvarial defects, and radiographic and histologic examination and histomorphometric analysis were performed. Results. In vitro studies confirmed physicochemical demands for collagen-based bone graft material, such as lowered calcium content, lowered crystallinity of hydroxyapatite, and exposed organic structures to demineralization. In vivo experiment indicated new bone formation in DDTP-grafted sites and gradual resorption of the grafted particles. Defect closure rate was significantly higher in the 8-week DDTP-grafted group compared with control (P < .05). Conclusions. Deciduous teeth had structural and physicochemical characteristics suitable for grafting with appropriate demineralization. Bone healing was observed to have successfully occurred in DDTP-grafted sites.
DOI
10.1016/j.oooo.2015.05.021
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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