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Demineralized deciduous tooth as a source of bone graft material: its biological and physicochemical characteristics

Title
Demineralized deciduous tooth as a source of bone graft material: its biological and physicochemical characteristics
Authors
Park, MiraeMah, Yon-JooKim, David-HyungjinKim, Eun-SukPark, Eun-Jin
Ewha Authors
박은진마연주
SCOPUS Author ID
박은진scopus; 마연주scopus
Issue Date
2015
Journal Title
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
ISSN
2212-4403JCR Link

1528-395XJCR Link
Citation
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY vol. 120, no. 3, pp. 307 - 314
Publisher
ELSEVIER SCIENCE INC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objective. To examine structural and physicochemical characteristics of demineralized deciduous tooth powder (DDTP) in relation to demineralization time and to present potential of using DDTP as a bone graft material. Study design. For structural and physicochemical analysis, scanning electron microscopy, inductively coupled plasma spectrometry, energy-dispersive X-ray analysis, X-ray diffraction analysis, differential scanning calorimetry, and Brunauer-Emmett-Teller surface area analysis were performed. In in vivo experiments, DDTP was grafted in 20 Sprague-Dawley rats' calvarial defects, and radiographic and histologic examination and histomorphometric analysis were performed. Results. In vitro studies confirmed physicochemical demands for collagen-based bone graft material, such as lowered calcium content, lowered crystallinity of hydroxyapatite, and exposed organic structures to demineralization. In vivo experiment indicated new bone formation in DDTP-grafted sites and gradual resorption of the grafted particles. Defect closure rate was significantly higher in the 8-week DDTP-grafted group compared with control (P < .05). Conclusions. Deciduous teeth had structural and physicochemical characteristics suitable for grafting with appropriate demineralization. Bone healing was observed to have successfully occurred in DDTP-grafted sites.
DOI
10.1016/j.oooo.2015.05.021
Appears in Collections:
의과대학 > 의학과 > Journal papers
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