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Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children

Title
Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children
Authors
Kwon, Jung HyunLee, Seung EunLee, Hye AhKim, Young JuLee, Hwa YoungGwak, Hye SunPark, Eun AeCho, Su JinOh, Se YoungHa, Eun HeePark, HyesookKim, Hae Soon
Ewha Authors
하은희박은애김영주김혜순박혜숙이화영곽혜선조수진이혜아권정현
SCOPUS Author ID
하은희scopus; 박은애scopus; 김영주scopus; 김혜순scopus; 박혜숙scopus; 이화영scopus; 곽혜선scopus; 조수진scopus; 이혜아scopus
Issue Date
2015
Journal Title
NUTRITION
ISSN
0899-9007JCR Link1873-1244JCR Link
Citation
vol. 31, no. 11-12, pp. 1324 - 1327
Keywords
Vitamin DDyslipidemiaChildren
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: The relationship between 25-hydroxyvitamin D (25[OH]D) levels and the lipid and metabolic levels of the prepubertal normal population is unclear. Our goals were to investigate the association of serum 25(OH)D concentrations with lipid and metabolic levels in Korean prepubertal children ages 7-9 y. Methods: We followed 205 children, ages 7-9 y in the Ewha Birth and Growth Cohort study, a prospective cohort sample established in 2001-2006, from July to August 2011. We studied the association of serum 25-hydroxyvitamin D (25[OH]D) levels with components of metabolic syndrome and insulin resistance indices using multivariate regression analysis adjusted for body mass index (BMI) z-scores. Results: The mean age of the 205 subjects was 7.89 +/- 0.85 y, and the sample included 109 boys (53.2%). The average 25(OH)D levels of all participants was 25.0 +/- 5.4 ng/mL. After adjustment for age and sex, triacylglycerol levels were significantly associated with 25(OH)D (beta = -0.02, P = 0.02) concentrations even after adjustment for BMI z-scores (beta = -0.02, P = 0.04). However, other metabolic components were not correlated with 25(OH)D status. Those with the lowest quartile of 25(OH)D levels had the highest serum triacylglycerol levels (P = 0.04, P-trend = 0.01). Conclusions: We found that serum 25(OH)D levels were negatively associated with serum triacylglycerol levels, even independently of adiposity, in prepubertal children. This study suggests that 25(OH)D insufficiency is related to metabolic syndrome via the derangement of triacylglycerol metabolism. (C) 2015 Elsevier Inc. All rights reserved.
DOI
10.1016/j.nut.2015.04.023
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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