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Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children
- Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children
- Kwon, Jung Hyun; Lee, Seung Eun; Lee, Hye Ah; Kim, Young Ju; Lee, Hwa Young; Gwak, Hye Sun; Park, Eun Ae; Cho, Su Jin; Oh, Se Young; Ha, Eun Hee; Park, Hyesook; Kim, Hae Soon
- Ewha Authors
- 하은희; 박은애; 김영주; 김혜순; 박혜숙; 이화영; 곽혜선; 조수진; 이혜아; 권정현
- SCOPUS Author ID
- 하은희; 박은애; 김영주; 김혜순; 박혜숙; 이화영; 곽혜선; 조수진; 이혜아
- Issue Date
- Journal Title
- 0899-9007; 1873-1244
- vol. 31, no. 11-12, pp. 1324 - 1327
- Vitamin D; Dyslipidemia; Children
- ELSEVIER SCIENCE INC
- SCI; SCIE; SCOPUS
- Objective: The relationship between 25-hydroxyvitamin D (25[OH]D) levels and the lipid and metabolic levels of the prepubertal normal population is unclear. Our goals were to investigate the association of serum 25(OH)D concentrations with lipid and metabolic levels in Korean prepubertal children ages 7-9 y. Methods: We followed 205 children, ages 7-9 y in the Ewha Birth and Growth Cohort study, a prospective cohort sample established in 2001-2006, from July to August 2011. We studied the association of serum 25-hydroxyvitamin D (25[OH]D) levels with components of metabolic syndrome and insulin resistance indices using multivariate regression analysis adjusted for body mass index (BMI) z-scores. Results: The mean age of the 205 subjects was 7.89 +/- 0.85 y, and the sample included 109 boys (53.2%). The average 25(OH)D levels of all participants was 25.0 +/- 5.4 ng/mL. After adjustment for age and sex, triacylglycerol levels were significantly associated with 25(OH)D (beta = -0.02, P = 0.02) concentrations even after adjustment for BMI z-scores (beta = -0.02, P = 0.04). However, other metabolic components were not correlated with 25(OH)D status. Those with the lowest quartile of 25(OH)D levels had the highest serum triacylglycerol levels (P = 0.04, P-trend = 0.01). Conclusions: We found that serum 25(OH)D levels were negatively associated with serum triacylglycerol levels, even independently of adiposity, in prepubertal children. This study suggests that 25(OH)D insufficiency is related to metabolic syndrome via the derangement of triacylglycerol metabolism. (C) 2015 Elsevier Inc. All rights reserved.
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