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Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms

Title
Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms
Authors
Lee, Seul BeeChoi, Han SeulSon, SejungHong, Young Mi
Ewha Authors
홍영미손세정
SCOPUS Author ID
홍영미scopus; 손세정scopus
Issue Date
2015
Journal Title
KOREAN CIRCULATION JOURNAL
ISSN
1738-5520JCR Link1738-5555JCR Link
Citation
vol. 45, no. 4, pp. 317 - 324
Keywords
Mucocutaneous lymph node syndromeReverse transcriptase polymerase chain reactionRespiratory virusNatriuretic peptide, brainEchocardiography, Doppler
Publisher
KOREAN SOC CARDIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background and Objectives: Respiratory symptoms are often observed in children with Kawasaki disease (KD) during the acute phase. The association of respiratory viruses in children with KD was investigated using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and tissue Doppler echocardiography. Subjects and Methods: 138 KD patients were included from January 2010 to June 2013. We compared 3 groups (group 1: n=94, KD without respiratory symptoms; group 2: n=44, KD with respiratory symptoms; and group 3: n=50, febrile patients with respiratory symptoms). Laboratory data were obtained from each patient including N-terminal pro-brain natriuretic peptide (NT-proBNP). Echocardiographic measurements were compared between group 1 and group 2. RT-PCR was performed using nasopharyngeal secretion to screen for the presence of 14 viruses in groups 2 and 3. Results: The incidence of KD with respiratory symptoms was 31.8%. The duration of fever was significantly longer, and coronary artery diameter was larger in group 2 than in group 1. Tei index was significantly higher and coronary artery diameter larger in group 2 than group 1. Coronary artery diameter, C-reactive protein levels, platelet count, alanine aminotransferase levels, and NT-pro BNP levels were significantly higher and albumin levels lower in group 2 compared with group 3. Conclusion: NT-pro BNP was a valuable diagnostic tool in differentiating KD from other febrile viral respiratory infections. Some viruses were more frequently observed in KD patients than in febrile controls. Tei index using tissue Doppler imaging was increased in KD patients with respiratory symptoms.
DOI
10.4070/kcj.2015.45.4.317
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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