View : 12 Download: 0

Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery

Title
Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery
Authors
Kim, Eun JiYang, InhoYoon, Yeo Joon
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2015
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link1976-3786JCR Link
Citation
vol. 38, no. 9, pp. 1606 - 1616
Keywords
Secondary metabolismHeterologous expressionS. venezuelaePathway engineering
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages, such as rapid growth rate, convenient genetic manipulation, and an abundant supply of common biosynthetic building blocks. In recent decades, several S. venezuelae mutant strains have been constructed and used to facilitate the synthesis and derivatization of diverse natural products. In this review article, we have provided a schematic look at these host strains, which were used to synthesize natural products from genetically engineered biosynthetic gene clusters.
DOI
10.1007/s12272-015-0638-z
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE