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Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease

Title
Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease
Authors
Ham, Jee HyunCha, JunghoLee, Jae JungBaek, Gwang-MinSunwoo, Mun KyungHong, Jin YongShin, Na-YoungSohn, Young HoLee, Jong-MinLee, Phil Hyu
Ewha Authors
신나영
SCOPUS Author ID
신나영scopus
Issue Date
2015
Journal Title
NEUROIMAGE
ISSN
1053-8119JCR Link1095-9572JCR Link
Citation
vol. 119, pp. 296 - 304
Keywords
Resting-state functional connectivityParkinson's diseaseDrug induced parkinsonismDopamine independent network
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
As an indicator of synchronous neural activity, resting-state functional networks are influenced by neuropathological and neurochemical changes in degenerative diseases. To further advance understanding about neurochemical and neuropathological basis for resting-state functional maps, we performed a comparative analysis of resting-state functional connectivity in patients with Parkinson's disease (PD) and drug induced parkinsonism (DIP). Resting-state neuroimaging data were analyzed with a seed-based approach to investigate striatocortical functional connectivity and cortical functional connectivity within the default mode network, executive control network, and the dorsal attention network. The striatal subregions were divided into the more or less affected sides in terms of dopamine transporter uptake. Compared with DIP, PD exhibited an increased cerebellar connectivity from the more affected side of the caudate and the less affected sides of the anterior and the posterior putamen. Additionally, PD showed increased functional connectivity in the anterior prefrontal areas from the more affected side of the anterior putamen and from the less affected side of the posterior putamen. However, PD exhibited decreased cortical functional connectivity from the posterior cingulate cortex in the left temporal area. Finally, DIP patients showed decreased cortical functional connectivity from the dorsolateral prefrontal cortex in frontal and parietal areas compared with PD patients. In summary, the present study demonstrates that PD patients exhibited a unique resting state functional connectivity that may be associated with PD-related pathological changes beyond the dopaminergic system, whereas DIP patients showed altered functional connectivity within executive control network. (C) 2015 Published by Elsevier Inc.
DOI
10.1016/j.neuroimage.2015.06.077
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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