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Development of fluorescent probes based on protection-deprotection of the key functional groups for biological imaging

Title
Development of fluorescent probes based on protection-deprotection of the key functional groups for biological imaging
Authors
Tang, YongheLee, DayoungWang, JiaoliangLi, GuanhanYu, JinghuaLin, WeiyingYoon, Juyoung
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2015
Journal Title
CHEMICAL SOCIETY REVIEWS
ISSN
0306-0012JCR Link1460-4744JCR Link
Citation
vol. 44, no. 15, pp. 5003 - 5015
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Recently, the strategy of protection-deprotection of functional groups has been widely employed to design fluorescent probes, as the protection-deprotection of functional groups often induces a marked change in electronic properties. Significant advances have been made in the development of analyte-responsive fluorescent probes based on the protection-deprotection strategy. In this tutorial review, we highlight the representative examples of small-molecule based fluorescent probes for bioimaging, which are operated via the protection-deprotection of key functional groups such as aldehyde, hydroxyl, and amino functional groups reported from 2010 to 2014. The discussion includes the general protection-deprotection methods for aldehyde, hydroxyl, or amino groups, as well as the design strategies, sensing mechanisms, and deprotection modes of the representative fluorescent imaging probes applied to bio-imaging.
DOI
10.1039/c5cs00103j
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자연과학대학 > 화학·나노과학전공 > Journal papers
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