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Development of fluorescent probes based on protection-deprotection of the key functional groups for biological imaging
- Development of fluorescent probes based on protection-deprotection of the key functional groups for biological imaging
- Tang, Yonghe; Lee, Dayoung; Wang, Jiaoliang; Li, Guanhan; Yu, Jinghua; Lin, Weiying; Yoon, Juyoung
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- CHEMICAL SOCIETY REVIEWS
- 0306-0012; 1460-4744
- vol. 44, no. 15, pp. 5003 - 5015
- ROYAL SOC CHEMISTRY
- SCI; SCIE; SCOPUS
- Recently, the strategy of protection-deprotection of functional groups has been widely employed to design fluorescent probes, as the protection-deprotection of functional groups often induces a marked change in electronic properties. Significant advances have been made in the development of analyte-responsive fluorescent probes based on the protection-deprotection strategy. In this tutorial review, we highlight the representative examples of small-molecule based fluorescent probes for bioimaging, which are operated via the protection-deprotection of key functional groups such as aldehyde, hydroxyl, and amino functional groups reported from 2010 to 2014. The discussion includes the general protection-deprotection methods for aldehyde, hydroxyl, or amino groups, as well as the design strategies, sensing mechanisms, and deprotection modes of the representative fluorescent imaging probes applied to bio-imaging.
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