View : 157 Download: 0
Visceral adipose tissue inflammation is associated with age-related brain changes and ischemic brain damage in aged mice
- Visceral adipose tissue inflammation is associated with age-related brain changes and ischemic brain damage in aged mice
- Shin, Jin A.; Jeong, Sae Im; Kim, Minsuk; Yoon, Joo Chun; Kim, Hee-Sun; Park, Eun-Mi
- Ewha Authors
- 김희선; 박은미; 윤주천; 김민석; 신진아
- SCOPUS Author ID
- 김희선; 박은미; 윤주천; 김민석; 신진아
- Issue Date
- Journal Title
- BRAIN BEHAVIOR AND IMMUNITY
- 0889-1591; 1090-2139
- vol. 50, pp. 221 - 231
- Aging; Adipose tissue inflammation; Blood-brain barrier; Ischemic stroke; Macrophage; Microglia; Proinflammatory cytokine; Tight junction protein; Visceral fat removal
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- SCI; SCIE; SCOPUS
- Visceral adipose tissue is accumulated with aging. An increase in visceral fat accompanied by low-grade inflammation is associated with several adult-onset diseases. However, the effects of visceral adipose tissue inflammation on the normal and ischemic brains of aged are not clearly defined. To examine the role of visceral adipose tissue inflammation, we evaluated inflammatory cytokines in the serum, visceral adipose tissue, and brain as well as blood-brain barrier (BBB) permeability in aged male mice (20 months) underwent sham or visceral fat removal surgery compared with the young mice (2.5 months). Additionally, ischemic brain injury was compared in young and aged mice with sham and visceral fat removal surgery. Interleukin (IL)-beta, IL-6, and tumor necrosis factor-alpha levels in examined organs were increased in aged mice compared with the young mice, and these levels were reduced in the mice with visceral fat removal. Increased BBB permeability with reduced expression of tight junction proteins in aged sham mice were also decreased in mice with visceral fat removal. After focal ischemic injury, aged mice with visceral fat removal showed a reduction in infarct volumes, BBB permeability, and levels of proinflammatory cytokines in the ischemic brain compared with sham mice, although the neurological outcomes were not significantly improved. In addition, further upregulated visceral adipose tissue inflammation in response to ischemic brain injury was attenuated in mice with visceral fat removal. These results suggest that visceral adipose tissue inflammation is associated with age-related changes in the brain and contributes to the ischemic brain damage in the aged mice. We suggest that visceral adiposity should be considered as a factor affecting brain health and ischemic brain damage in the aged population. (C) 2015 Elsevier Inc. All rights reserved.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.