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Visceral adipose tissue inflammation is associated with age-related brain changes and ischemic brain damage in aged mice

Title
Visceral adipose tissue inflammation is associated with age-related brain changes and ischemic brain damage in aged mice
Authors
Shin, Jin A.Jeong, Sae ImKim, MinsukYoon, Joo ChunKim, Hee-SunPark, Eun-Mi
Ewha Authors
김희선박은미윤주천김민석신진아
SCOPUS Author ID
김희선scopus; 박은미scopus; 윤주천scopus; 김민석scopus; 신진아scopus
Issue Date
2015
Journal Title
BRAIN BEHAVIOR AND IMMUNITY
ISSN
0889-1591JCR Link1090-2139JCR Link
Citation
vol. 50, pp. 221 - 231
Keywords
AgingAdipose tissue inflammationBlood-brain barrierIschemic strokeMacrophageMicrogliaProinflammatory cytokineTight junction proteinVisceral fat removal
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Visceral adipose tissue is accumulated with aging. An increase in visceral fat accompanied by low-grade inflammation is associated with several adult-onset diseases. However, the effects of visceral adipose tissue inflammation on the normal and ischemic brains of aged are not clearly defined. To examine the role of visceral adipose tissue inflammation, we evaluated inflammatory cytokines in the serum, visceral adipose tissue, and brain as well as blood-brain barrier (BBB) permeability in aged male mice (20 months) underwent sham or visceral fat removal surgery compared with the young mice (2.5 months). Additionally, ischemic brain injury was compared in young and aged mice with sham and visceral fat removal surgery. Interleukin (IL)-beta, IL-6, and tumor necrosis factor-alpha levels in examined organs were increased in aged mice compared with the young mice, and these levels were reduced in the mice with visceral fat removal. Increased BBB permeability with reduced expression of tight junction proteins in aged sham mice were also decreased in mice with visceral fat removal. After focal ischemic injury, aged mice with visceral fat removal showed a reduction in infarct volumes, BBB permeability, and levels of proinflammatory cytokines in the ischemic brain compared with sham mice, although the neurological outcomes were not significantly improved. In addition, further upregulated visceral adipose tissue inflammation in response to ischemic brain injury was attenuated in mice with visceral fat removal. These results suggest that visceral adipose tissue inflammation is associated with age-related changes in the brain and contributes to the ischemic brain damage in the aged mice. We suggest that visceral adiposity should be considered as a factor affecting brain health and ischemic brain damage in the aged population. (C) 2015 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbi.2015.07.008
Appears in Collections:
의과대학 > 의학과 > Journal papers
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