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Administration of red ginseng ameliorates memory decline in aged mice

Title
Administration of red ginseng ameliorates memory decline in aged mice
Authors
Lee, YeonjuOh, Seikwan
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2015
Journal Title
JOURNAL OF GINSENG RESEARCH
ISSN
1226-8453JCR Link2093-4947JCR Link
Citation
vol. 39, no. 3, pp. 250 - 256
Keywords
agingantioxidationinflammationmemoryPanax ginseng
Publisher
KOREAN SOC GINSENG
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background: It has been known that ginseng can be applied as a potential nutraceutical for memory impairment; however, experiments with animals of old age are few. Methods: To determine the memory enhancing effect of red ginseng, C57BL/6 mice (21 mo old) were given experimental diet pellets containing 0.12% red ginseng extract (approximately 200 mg/kg/d) for 3 mo. Young and old mice (4 mo and 21 mo old, respectively) were used as the control group. The effect of red ginseng, which ameliorated memory impairment in aged mice, was quantified using Y-maze test, novel objective test, and Morris water maze. Red ginseng ameliorated age-related declines in learning and memory in older mice. In addition, red ginseng's effect on the induction of inducible nitric oxide synthase and proinflammatory cytokines was investigated in the hippocampus of aged mice. Results: Red ginseng treatment suppressed the production of age-processed inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, and interleukin-1 beta expressions. Moreover, it was observed that red ginseng had an antioxidative effect on aged mice. The suppressed glutathione level in aged mice was restored with red ginseng treatment. The antioxidative-related enzymes Nrf2 and HO-1 were increased with red ginseng treatment. Conclusion: The results revealed that when red ginseng is administered over long periods, age-related decline of learning and memory is ameliorated through anti-inflammatory activity. Copyright (C) 2015, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.
DOI
10.1016/j.jgr.2015.01.003
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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