Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김범산 | * |
dc.contributor.author | 김예미 | * |
dc.contributor.author | 윤혜전 | * |
dc.date.accessioned | 2016-08-27T04:08:46Z | - |
dc.date.available | 2016-08-27T04:08:46Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1738-6756 | * |
dc.identifier.issn | 2092-9900 | * |
dc.identifier.other | OAK-15238 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217375 | - |
dc.description.abstract | Purpose: This study assessed the axillary lymph node (ALN)-to-primary tumor maximum standard uptake value (SUVmax.) ratio (ALN/T SUV ratio) in invasive ductal breast cancer (IDC) on preoperative F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to determine the effectiveness in predicting recurrence-free survival (RFS). Methods: One hundred nineteen IDC patients (mean age, 50.5 +/- 10.5 years) with pathologically proven ALN involvement without distant metastasis and preoperative FDG PET/CT were enrolled in the study. SUVmax values of the ALN and primary tumor were obtained on FDG PET/CT, and ALN/T SUV ratio was calculated. Several factors were evaluated for their effectiveness in predicting RFS. These included several parameters on FOG PET/CT as well as several clinicopathological parameters: pathologic tumor/node stage; nuclear and histological grade; hormonal state; status with respect to human epidermal growth factor receptor 2, mindbomb E3 ubiquitin protein ligase 1 (MIB-1), and p53; primary tumor size; and ALN size. Results: Among 119 patients with breast cancer, 17 patients (14.3%) experienced relapse during follow-up (mean follow-up, 28.4 months). The ALN/T SUV ratio of the group with disease recurrence was higher than that of the group without recurrence (0.97 +/- 1.60 and 0.45 +/- 0.40, respectively, p=0.005). Univariate analysis showed that the primary tumor SUVmax, ALN SUVmax, ALN/T SUV ratio, ALN status, nuclear and histological grade, estrogen receptor (ER) status, and MIB-1 status were predictors for RFS. Among these variables, ALN/T SUV ratio with hazard ratio of 4.20 (95% confidence interval [CI], 1.74-10.13) and ER status with hazard ratio of 4.33 (95% CI, 1.06-17.71) were predictors for RFS according to multivariate analysis (p=0.002 and p=0.042, respectively). Conclusion: Our study demonstrated that ALN/T SUV ratio together with ER status was an independent factor for predicting relapse in IDC with metastatic ALN. ALN/T SUV ratio on preoperative FDG PET/CT may be a useful marker for selecting IDC patients that need adjunct treatment to prevent recurrence. | * |
dc.language | English | * |
dc.publisher | KOREAN BREAST CANCER SOC | * |
dc.subject | Breast neoplasms | * |
dc.subject | Fluorodeoxyglucose F18 | * |
dc.subject | Lymph nodes | * |
dc.subject | Prognosis | * |
dc.title | Axillary Lymph Node-to-Primary Tumor Standard Uptake Value Ratio on Preoperative F-18-FDG PET/CT: A Prognostic Factor for Invasive Ductal Breast Cancer | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 173 | * |
dc.relation.lastpage | 180 | * |
dc.relation.journaltitle | JOURNAL OF BREAST CANCER | * |
dc.identifier.doi | 10.4048/jbc.2015.18.2.173 | * |
dc.identifier.wosid | WOS:000357767200010 | * |
dc.identifier.scopusid | 2-s2.0-84935131815 | * |
dc.author.google | Kim, Young Hwan | * |
dc.author.google | Yoon, Hai-Jeon | * |
dc.author.google | Kim, Yemi | * |
dc.author.google | Kim, Bom Sahn | * |
dc.contributor.scopusid | 김범산(35223582600) | * |
dc.contributor.scopusid | 김예미(36059180800) | * |
dc.contributor.scopusid | 윤혜전(47161772300) | * |
dc.date.modifydate | 20240222164135 | * |