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Prospective study of body fat distribution and the risk of endometrial cancer

Title
Prospective study of body fat distribution and the risk of endometrial cancer
Authors
Ju, WoongKim, Hyun JaHankinson, Susan E.De Vivo, ImmaculataCho, Eunyoung
Ewha Authors
주웅
SCOPUS Author ID
주웅scopus
Issue Date
2015
Journal Title
CANCER EPIDEMIOLOGY
ISSN
1877-7821JCR Link1877-783XJCR Link
Citation
vol. 39, no. 4, pp. 567 - 570
Keywords
Body fat distributionEndometrial cancerProspective cohort study
Publisher
ELSEVIER SCI LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Epidemiologic studies have found that overall obesity is positively related to endometrial cancer (EC) risk. However, data assessing the association between body fat distribution and risk of EC are still limited. Methods: We followed 51,948 women who first reported waist circumference (WC) and hip circumference in 1986 in the Nurses' Health Study. Waist-to-hip ratio (WHR) was calculated. Results: During 24 years of follow-up, 449 incident invasive EC cases were diagnosed. In a multivariate analysis without adjusting for body mass index (BMI), the relative risks (RRs) for EC comparing extreme categories were 2.44 (95% confidence interval [CI] 1.72-3.45) for WC and 1.69 (95% CI = 1.20-2.40) for WHR. However, after adjustment of BMI, those positive associations were substantially attenuated and no longer significant; RR = 1.08 (95% CI = 0.69-1.67) for WC and 1.15 (95% CI = 0.81-1.64) for WHR, respectively. Conclusion: In our prospective cohort study, we found no independent association between body fat distribution and the risk of EC after adjustment for BMI. (C) 2015 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.canep.2015.05.003
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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