Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상혁 | * |
dc.contributor.author | 강상원 | * |
dc.contributor.author | 김재상 | * |
dc.contributor.author | 이두재 | * |
dc.contributor.author | 정연주 | * |
dc.contributor.author | 강동훈 | * |
dc.date.accessioned | 2016-08-27T04:08:38Z | - |
dc.date.available | 2016-08-27T04:08:38Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0008-6363 | * |
dc.identifier.issn | 1755-3245 | * |
dc.identifier.other | OAK-15077 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217295 | - |
dc.description.abstract | Aims Pro-inflammatory response of vascular smooth muscle cells (VSMCs) is triggered by endothelial damage and a causative step for thrombosis and neointimal thickening in the injured arterial vessels. Therefore, we investigate a role of cytosolic Hsp60 as a novel pro-inflammatory mediator in VSMCs. Methods and results Hsp60 was detected in the cytosol of VSMCs. The selective depletion of cytosolic Hsp60 in VSMCs reduced the I kappa B kinase activation, repressed the induction of nuclear factor (NF)-kappa B-dependent survival genes (MnSOD and Bfl-1/A1), and enhanced apoptotic death in response to TNF-alpha Moreover, a quantitative RNA sequencing revealed that the expression of 75 genes among the 774 TNF-alpha-inducible genes was significantly reduced by the depletion of cytosolic Hsp60. In particular, the expression of pro-inflammatory cytokines/chemokines, such as CCL2, CCL20, and IL-6, was regulated by the cytosolic Hsp60 in VSMCs. Finally, the depletion of cytosolic Hsp60 markedly inhibited the neointimal thickening in the balloon-injured arterial vessels by inducing apoptotic cell death and inhibiting chemokine production. Conclusions This study provides the first evidence that cytosolic Hsp60 could be a therapeutic target for preventing VSMC hyperplasia and inflammatory response in the injured vessels. | * |
dc.language | English | * |
dc.publisher | OXFORD UNIV PRESS | * |
dc.subject | Hsp60 | * |
dc.subject | Vascular smooth muscle cells | * |
dc.subject | NF-kappa B | * |
dc.subject | Inflammation | * |
dc.subject | Restenosis | * |
dc.title | Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 106 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 498 | * |
dc.relation.lastpage | 508 | * |
dc.relation.journaltitle | CARDIOVASCULAR RESEARCH | * |
dc.identifier.doi | 10.1093/cvr/cvv130 | * |
dc.identifier.wosid | WOS:000359088400017 | * |
dc.identifier.scopusid | 2-s2.0-84930366398 | * |
dc.author.google | Choi, Boae | * |
dc.author.google | Choi, Mina | * |
dc.author.google | Park, Charny | * |
dc.author.google | Lee, Eun Kyung | * |
dc.author.google | Kang, Dong Hoon | * |
dc.author.google | Lee, Doo Jae | * |
dc.author.google | Yeom, Jae Yoon | * |
dc.author.google | Jung, Yeonjoo | * |
dc.author.google | Kim, Jaesang | * |
dc.author.google | Lee, Sanghyuk | * |
dc.author.google | Kang, Sang Won | * |
dc.contributor.scopusid | 이상혁(57212112170) | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.contributor.scopusid | 이두재(26652094200) | * |
dc.contributor.scopusid | 정연주(8777976600) | * |
dc.contributor.scopusid | 강동훈(57033374200) | * |
dc.date.modifydate | 20240415122632 | * |