Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안영호 | * |
dc.date.accessioned | 2016-08-27T04:08:37Z | - |
dc.date.available | 2016-08-27T04:08:37Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 2041-1723 | * |
dc.identifier.other | OAK-15062 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217282 | - |
dc.description.abstract | Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We demonstrate here a molecular link between epithelial-to-mesenchymal transition (EMT) and CD8(+) TIL immunosuppression, two key drivers of cancer progression. We show that microRNA-200 (miR-200), a cell-autonomous suppressor of EMT and metastasis, targets PD-L1. Moreover, ZEB1, an EMTactivator and transcriptional repressor of miR-200, relieves miR-200 repression of PD-L1 on tumour cells, leading to CD8(+) T-cell immunosuppression and metastasis. These findings are supported by robust correlations between the EMT score, miR-200 levels and PD-L1 expression in multiple human lung cancer datasets. In addition to revealing a link between EMT and T-cell dysfunction, these findings also show that ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and suggest that subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression | * |
dc.type | Article | * |
dc.relation.volume | 5 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NATURE COMMUNICATIONS | * |
dc.identifier.doi | 10.1038/ncomms6241 | * |
dc.identifier.wosid | WOS:000354989000002 | * |
dc.author.google | Chen, Limo | * |
dc.author.google | Gibbons, Don L. | * |
dc.author.google | Goswami, Sangeeta | * |
dc.author.google | Cortez, Maria Angelica | * |
dc.author.google | Ahn, Young-Ho | * |
dc.author.google | Byers, Lauren A. | * |
dc.author.google | Zhang, Xuejun | * |
dc.author.google | Yi, Xiaohui | * |
dc.author.google | Dwyer, David | * |
dc.author.google | Lin, Wei | * |
dc.author.google | Diao, Lixia | * |
dc.author.google | Wang, Jing | * |
dc.author.google | Roybal, Jonathon D. | * |
dc.author.google | Patel, Mayuri | * |
dc.author.google | Ungewiss, Christin | * |
dc.author.google | Peng, David | * |
dc.author.google | Antonia, Scott | * |
dc.author.google | Mediavilla-Varela, Melanie | * |
dc.author.google | Robertson, Gordon | * |
dc.author.google | Jones, Steve | * |
dc.author.google | Suraokar, Milind | * |
dc.author.google | Welsh, James W. | * |
dc.author.google | Erez, Baruch | * |
dc.author.google | Wistuba, Ignacio I. | * |
dc.author.google | Chen, Lieping | * |
dc.author.google | Peng, Di | * |
dc.author.google | Wang, Shanshan | * |
dc.author.google | Ullrich, Stephen E. | * |
dc.author.google | Heymach, John V. | * |
dc.author.google | Kurie, Jonathan M. | * |
dc.author.google | Qin, F. Xiao-Feng | * |
dc.contributor.scopusid | 안영호(7202402440) | * |
dc.date.modifydate | 20240222132209 | * |