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The use of low-volume polyethylene glycol containing ascorbic acid versus 2 L of polyethylene glycol plus bisacodyl as bowel preparation for colonoscopy

Title
The use of low-volume polyethylene glycol containing ascorbic acid versus 2 L of polyethylene glycol plus bisacodyl as bowel preparation for colonoscopy
Authors
Tae, Chung HyunJung, Sung-AeNa, Sun-KyungSong, Hye-KyungMoon, Chang MoKim, Seong-EunShim, Ki-NamJung, Hye-KyungMoon, Il Hwan
Ewha Authors
문일환정성애정혜경심기남김성은문창모태정현
SCOPUS Author ID
문일환scopus; 정성애scopus; 정혜경scopus; 심기남scopus; 김성은scopus; 문창모scopus; 태정현scopusscopus
Issue Date
2015
Journal Title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
ISSN
0036-5521JCR Link1502-7708JCR Link
Citation
vol. 50, no. 8, pp. 1039 - 1044
Keywords
ascorbic acidbisacodylbowel preparation solutionscolonoscopypolyethylene glycol
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective. Low-volume polyethylene glycol (PEG) bowel preparations have been developed to improve compliance for colonoscopy. Our study aimed to compare the efficacy and tolerability of low-volume PEG containing ascorbic acid for colonoscopy against 2 L of PEG plus bisacodyl. Methods. We prospectively enrolled consecutive inpatients who had not undergone polypectomy at the index colonoscopy and were subsequently referred for polypectomy at our hospital. A total of 62 patients were randomized to receive either low-volume PEG containing ascorbic acid (n = 31) or 2 L of PEG plus bisacodyl (n = 31) as a split-dose regimen in inpatients. The efficacy of preparation was determined using the Ottawa Bowel Preparation Score (OBPS) and a 4-point scale. Adverse events, tolerability, and willingness were evaluated using a questionnaire. Results. Based on the OBPS and 4-point scale, we determined that the efficacy of low-volume PEG containing ascorbic acid was comparable to that of the 2 L of PEG plus bisacodyl (p = 0.071 for OBPS, p = 0.056 for the 4-point scale). Adverse events were comparable between the two groups (p = 1.000). A greater proportion of patients in the low-volume PEG containing ascorbic acid (90.6%) and the 2L of PEG plus bisacodyl (96.9%) were willing to repeat the same preparation for subsequent colonoscopy. Conclusion. Low-volume PEG containing ascorbic acid had comparable efficacy and tolerability to 2 L of PEG plus bisacodyl, when given as a split dose, for colonoscopy in inpatients. Split-dose low-volume PEG containing ascorbic acid is a good alternative for bowel preparation for colonoscopy in inpatients.
DOI
10.3109/00365521.2014.1000961
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의학전문대학원 > 의학과 > Journal papers
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