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Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C)

Title
Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C)
Authors
Paltiel, OraTikellis, GabriellaLinet, MarthaGolding, JeanLemeshow, StanleyPhillips, GaryLamb, KarenStoltenberg, CamillaHaberg, Siri E.Strom, MarinGranstrom, CharlottaNorthstone, KateKlebanoff, MarkPonsonby, Anne-LouiseMilne, ElizabethPedersen, MarieKogevinas, ManolisHa, EunheeDwyer, TerenceInt Childhood Canc Cohort Consorti
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2015
Journal Title
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
ISSN
0269-5022JCR Link1365-3016JCR Link
Citation
vol. 29, no. 4, pp. 335 - 345
Keywords
Childhood cancerleukemiacohort studiespooled analysis
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BackgroundEvidence relating childhood cancer to high birthweight is derived primarily from registry and case-control studies. We aimed to investigate this association, exploring the potential modifying roles of age at diagnosis and maternal anthropometrics, using prospectively collected data from the International Childhood Cancer Cohort Consortium. MethodsWe pooled data on infant and parental characteristics and cancer incidence from six geographically and temporally diverse member cohorts [the Avon Longitudinal Study of Parents and Children (UK), the Collaborative Perinatal Project (USA), the Danish National Birth Cohort (Denmark), the Jerusalem Perinatal Study (Israel), the Norwegian Mother and Child Cohort Study (Norway), and the Tasmanian Infant Health Survey (Australia)]. Birthweight metrics included a continuous measure, deciles, and categories (4.0 vs. <4.0 kilogram). Childhood cancer (377 cases diagnosed prior to age 15 years) risk was analysed by type (all sites, leukaemia, acute lymphoblastic leukaemia, and non-leukaemia) and age at diagnosis. We estimated hazard ratios (HR) and 95% confidence intervals (CI) from Cox proportional hazards models stratified by cohort. ResultsA linear relationship was noted for each kilogram increment in birthweight adjusted for gender and gestational age for all cancers [HR=1.26; 95% CI 1.02, 1.54]. Similar trends were observed for leukaemia. There were no significant interactions with maternal pre-pregnancy overweight or pregnancy weight gain. Birthweight 4.0kg was associated with non-leukaemia cancer among children diagnosed at age 3 years [HR=1.62; 95% CI 1.06, 2.46], but not at younger ages [HR=0.7; 95% CI 0.45, 1.24, P for difference=0.02]. ConclusionChildhood cancer incidence rises with increasing birthweight. In older children, cancers other than leukaemia are particularly related to high birthweight. Maternal adiposity, currently widespread, was not demonstrated to substantially modify these associations. Common factors underlying foetal growth and carcinogenesis need to be further explored.
DOI
10.1111/ppe.12193
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의학전문대학원 > 의학과 > Journal papers
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