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Indoor total volatile organic compounds exposure at 6months followed by atopic dermatitis at 3 years in children

Title
Indoor total volatile organic compounds exposure at 6months followed by atopic dermatitis at 3 years in children
Authors
Kwon, Jung HyunKim, EunjeongChang, Moon-HeePark, Eun AeHong, Yun-ChulHa, MinaPark, HyesookKim, YanghoPark, ChoongheeHa, Eun-Hee
Ewha Authors
하은희박은애박혜숙권정현
SCOPUS Author ID
하은희scopus; 박은애scopus; 박혜숙scopus
Issue Date
2015
Journal Title
PEDIATRIC ALLERGY AND IMMUNOLOGY
ISSN
0905-6157JCR Link1399-3038JCR Link
Citation
vol. 26, no. 4, pp. 352 - 358
Keywords
atopic dermatitischildvolatile organic compounds
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BackgroundExposure to indoor air pollutants is thought to cause allergic inflammation. Volatile organic compounds (VOCs) are one of the aggravating factors of asthma and other allergic diseases. However, the influence of VOCs on development of atopic dermatitis is ambiguous in the clinical field. We therefore investigated the associations of indoor total volatile organic compounds (TVOCs) and development of atopic dermatitis in young Korean children. MethodsFrom the birth cohort of a MOthers and Children's Environmental Health (MOCEH) study, 257 infants, whose parents agreed with the environmental measurement, were enrolled. Total VOCs were measured in infant's bedrooms at the age of 6month. A total of 105 parents answered a questionnaire at 36month. Concentrations of TVOCs were divided into two groups by third quartile (75th). Associations between the high VOCs exposure group and development of atopic dermatitis at the age of 36months were estimated by multivariate logistic regression. ResultsThe average concentration of TVOCs was 174.7115.1?/m(3). We defined the high TVOCs exposure group by those with more than 75 percentile of the distribution (242.1?/m(3)). An increased risk of atopic dermatitis was observed in the high TVOCs exposure group, after adjustment for parents history of allergy, household income, breast-feeding longer than 6month (OR=3.116, 95% Cl 1.041-9.323). Risk of atopic dermatitis was increased when the family bought new furniture within 1yr. ConclusionOur results showed that exposure to high concentration of VOCs during infancy, an indoor pollutant, increased the risk of atopic dermatitis at 36months.
DOI
10.1111/pai.12393
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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