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Src enhances osteogenic differentiation through phosphorylation of Osterix

Title
Src enhances osteogenic differentiation through phosphorylation of Osterix
Authors
Choi, You HeeHan, YounHoLee, Sung HoCheong, HeesunChun, Kwang-HoonYeo, Chang-YeolLee, Kwang Youl
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2015
Journal Title
MOLECULAR AND CELLULAR ENDOCRINOLOGY
ISSN
0303-7207JCR Link
Citation
vol. 407, no. C, pp. 85 - 97
Keywords
SrcOsterixPhosphorylationOsteoblastDifferentiation
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Osterix, a zinc-finger transcription factor, is required for osteoblast differentiation and new bone formation during embryonic development. The c-Src of tyrosine kinase is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization. Src activity is tightly regulated and its dysregulation leads to constitutive activation and cellular transformation. The function of Osterix can be also modulated by post-translational modification. But the precise molecular signaling mechanisms between Osterix and c-Src are not known. In this study we investigated the potential regulation of Osterix function by c-Src in osteoblast differentiation. We found that c-Src activation increases protein stability, osteogenic activity and transcriptional activity of Osterix. The siRNA-mediated knockdown of c-Src decreased the protein levels and transcriptional activity of Osterix. Conversely, Src specific inhibitor, SU6656, decreased the protein levels and transcriptional activity of Osterix. The c-Src interacts with and phosphorylates Osterix These results suggest that c-Src signaling modulates osteoblast differentiation at least in part through Osterix. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.mce.2015.03.010
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자연과학대학 > 생명과학전공 > Journal papers
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