Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김광현 | * |
dc.date.accessioned | 2016-08-27T04:08:27Z | - |
dc.date.available | 2016-08-27T04:08:27Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1932-6203 | * |
dc.identifier.other | OAK-14875 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217187 | - |
dc.description.abstract | Remote ischemic preconditioning (IP) is a potential renoprotective strategy. However, there has been no demonstrated result in large animals and the role of time window in remote IP remains to be defined. Using a single-kidney porcine model, we evaluated organ protective function of remote IP in renal ischemia reperfusion injury. Fifteen Yorkshire pigs, 20 weeks old and weighing 35-38 kg were used. One week after left nephrectomy, we performed remote IP (clamping right external iliac artery, 2 cycles of 10 minutes) and right renal artery clamping (warm ischemia; 90 minutes). The animals were randomly divided into three groups: control group, warm ischemia without IP; group 1 (remote IP with early window [IP-E]), IP followed by warm ischemia with a 10-minute time window; and group 2 (remote IP with late window [IP-L]), IP followed by warm ischemia after a 24-hour time window. There were no differences in serum creatinine changes between groups. The IP-L group had lower urinary neutrophil gelatinase-associated lipocalin than control and IP-E at 72 hours post-ischemia. At 72 hours post-ischemia, the urinary kidney injury molecule-1 (KIM-1) was lower in the IP-L group than in the control and IP-E groups, and the IP-L group KIM-1 was near pre-ischemic levels, whereas the control and IP-E group KIM-1 levels were rising. Microalbumin also tended to be lower in the IP-L group. Taken together, remote IP showed a significant reduction in renal injury biomarkers from ischemia reperfusion injury. To effectively provide kidney protection, remote IP might require a considerable, rather than short, time window of ischemia. | * |
dc.language | English | * |
dc.publisher | PUBLIC LIBRARY SCIENCE | * |
dc.title | Preconditioning Strategies for Kidney Ischemia Reperfusion Injury: Implications of the "Time-Window" in Remote Ischemic Preconditioning | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 10 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PLOS ONE | * |
dc.identifier.doi | 10.1371/journal.pone.0124130 | * |
dc.identifier.wosid | WOS:000353016500084 | * |
dc.identifier.scopusid | 2-s2.0-84928492377 | * |
dc.author.google | Yoon, Young Eun | * |
dc.author.google | Lee, Kwang Suk | * |
dc.author.google | Choi, Kyung Hwa | * |
dc.author.google | Kim, Kwang Hyun | * |
dc.author.google | Yang, Seung Choul | * |
dc.author.google | Han, Woong Kyu | * |
dc.contributor.scopusid | 김광현(57191527009) | * |
dc.contributor.scopusid | 김광현(22234001900) | * |
dc.date.modifydate | 20240222163024 | * |