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Oxidized LDL induces phosphorylation of non-muscle myosin IIA heavy chain in macrophages

Title
Oxidized LDL induces phosphorylation of non-muscle myosin IIA heavy chain in macrophages
Authors
Park, Young Mi
Ewha Authors
박영미
SCOPUS Author ID
박영미scopus
Issue Date
2015
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link1976-670XJCR Link
Citation
vol. 48, no. 1, pp. 48 - 53
Keywords
AtherosclerosisCD36MacrophageNon-muscle myosinOxidized LDL
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Oxidized LDL (oxLDL) performs critical roles in atherosclerosis by inducing macrophage foam cell formation and promoting inflammation. There have been reports showing that oxLDL modulates macrophage cytoskeletal functions for oxLDL uptake and trapping, however, the precise mechanism has not been clearly elucidated. Our study examined the effect of oxLDL on non-muscle myosin heavy chain IIA (MHC-IIA) in macrophages. We demonstrated that oxLDL induces phosphorylation of MHC-IIA (Ser1917) in peritoneal macrophages from wild-type mice and THP-1, a human monocytic cell line, but not in macrophages deficient for CD36, a scavenger receptor for oxLDL. Protein kinase C (PKC) inhibitor-treated macrophages did not undergo the oxLDL-induced MHC-IIA phosphorylation. Our immunoprecipitation revealed that oxLDL increased physical association between PKC and MHC-IIA, supporting the role of PKC in this process. We conclude that oxLDL via CD36 induces PKC-mediated MHC-IIA (Ser1917) phosphorylation and this may affect oxLDL-induced functions of macrophages involved in atherosclerosis.
DOI
10.5483/BMBRep.2015.48.1.186
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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