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Excimers Beyond Pyrene: A Far-Red Optical Proximity Reporter and its Application to the Label-Free Detection of DNA

Title
Excimers Beyond Pyrene: A Far-Red Optical Proximity Reporter and its Application to the Label-Free Detection of DNA
Authors
Han, GaramKim, DongwookPark, YounbongBouffard, JeanKim, Youngmi
Ewha Authors
Jean Bouffard
SCOPUS Author ID
Jean Bouffardscopus
Issue Date
2015
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851JCR Link1521-3773JCR Link
Citation
vol. 54, no. 13, pp. 3912 - 3916
Keywords
aggregationchromophoresDNA detectionexcimersfluorescence
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
A family of organic chromophores that, like pyrene, forms emissive excimers is reported. Their chemical and photophysical properties are superior to pyrene for the design of chemo- and biosensors. Unlike hydrophobic pyrene, which requires excitation by cell-damaging UV irradiation, these polar dyes absorb strongly in the visible range, and their excimers emit brightly in the red to far-red region of the electromagnetic spectrum. The intensity of the emission signal is greatly increased upon formation of a preassociated dimer that is triggered upon aggregation or crystallization. In demonstration of the potential of this new family of excimer-forming dyes, a probe that is capable of detecting label-free DNA in water down to 10 pm and also doubles as a visualization agent for DNA in gel electrophoresis is reported.
DOI
10.1002/anie.201410548
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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