View : 41 Download: 0

Effect of maternal excessive sodium intake on postnatal brain development in rat offspring

Title
Effect of maternal excessive sodium intake on postnatal brain development in rat offspring
Authors
Shin, Jung-aAhn, Young-moLee, Hye-ahPark, HyesookKim, Young-juLee, Hwa-young
Ewha Authors
김영주박혜숙이화영신정아이혜아
SCOPUS Author ID
김영주scopus; 박혜숙scopus; 이화영scopus; 신정아scopus; 이혜아scopus
Issue Date
2015
Journal Title
NUTRITIONAL NEUROSCIENCE
ISSN
1028-415XJCR Link1476-8305JCR Link
Citation
vol. 18, no. 3, pp. 118 - 124
Keywords
BrainDevelopmentPregnancyRatSodium
Publisher
MANEY PUBLISHING
Indexed
SCIE; SCOPUS WOS
Abstract
Objectives: Postnatal brain development is affected by the in utero environment. Modern people usually have a high sodium intake. The aim of this study was to investigate the effect of sodium hyperingestion during pregnancy on the postnatal brain development of rat offspring. Methods: The sodium-overloaded rats received 1.8% NaCl in their drinking water for 7 days during the last week of gestation. Their body weight, urine, and blood levels of sodium and other parameters were measured. Some rats were sacrificed at pregnancy day 22 and the weight and length of the placenta and foetus were measured. The cerebral cortex and hippocampus were obtained from their offspring at postnatal day 1 and at postnatal weeks 1, 2, 4, and 8. Western blot analyses were conducted with brain tissue lysates. Results: The sodium-overloaded animals had decreased weight gain in the last week of gestation as well as decreased food intake, increased water intake, urine volume, urine sodium, and serum sodium. There were no differences in placental weight and length. The foetuses of sodium-overloaded rats showed decreased body weight and size, and this difference was maintained postnatally for 2 weeks. In the cerebral cortex and hippocampus of the offspring, the protein levels of myelin basic protein, calmodulin/calcium-dependent protein kinase II, and brain-derived neurotrophic factor were decreased or aberrantly expressed. Discussion: The present data suggest that increased sodium intake during pregnancy affects the brain development of the offspring.
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE