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Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells

Title
Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells
Authors
Park, MinhwaKim, Yu-HeeRyu, Jung-HwaWoo, So-YounRyu, Kyung-Ha
Ewha Authors
유경하우소연김유희
SCOPUS Author ID
유경하scopus; 우소연scopus; 김유희scopus
Issue Date
2015
Journal Title
STEM CELLS INTERNATIONAL
ISSN
1687-966XJCR Link1687-9678JCR Link
Publisher
HINDAWI PUBLISHING CORPORATION
Indexed
SCIE WOS
Abstract
Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow-(BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4(+) T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colonystimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.
DOI
10.1155/2015/106540
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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