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Clinical associations between metabolic syndrome and the development of microalbuminuria in Korean men

Title
Clinical associations between metabolic syndrome and the development of microalbuminuria in Korean men
Authors
Ryoo, Jae-HongChun, HyejinLee, Hong-SooSuh, EunkyungChoi, Joong-MyungKim, Min-GiShin, HoCheolPark, Sung KeunOh, Chang-MoKo, Taeg Su
Ewha Authors
이홍수전혜진
SCOPUS Author ID
이홍수scopus; 전혜진scopus
Issue Date
2015
Journal Title
DIABETES RESEARCH AND CLINICAL PRACTICE
ISSN
0168-8227JCR Link1872-8227JCR Link
Citation
vol. 107, no. 3, pp. 407 - 414
Keywords
Metabolic syndromeMicroalbuminuriaUrine albumin creatinine ratio
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Aims: There have been several studies on the association between metabolic syndrome (MetS) and microalbuminuria. However, none has examined whether MetS is associated with the prospective development of microalbuminuria. Accordingly, we performed a prospective study to evaluate the longitudinal effects of baseline number of MetS traits on the development of microalbuminuria in Korean men. Methods: 1649 Korean men without microalbuminuria in 2005 were included and followed prospectively until 2010 with the endpoint being the development of microalbuminuria. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Microalbuminuria was evaluated by urine albumin creatinine ratio (UACR). Risk estimations for development of microalbuminuria were analyzed according to the number of MetS traits using multivariate adjusted Cox proportional hazards model. Results: During 5611.8 person-years of follow-up (median 3.40 +/- 1.46 years), microalbuminuria developed in 91 (5.5%) participants between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% confidence interval) for development of microalbuminuria comparing 1, 2 and 3-5 MetS traits vs 0 were 2.57 (0.97-6.82), 2.94 (1.09-7.98) and 3.85 (1.37-10.86), respectively. Conclusions: The number of MetS traits independently associated with the future development of microalbuminuria during the 5-year follow-up period, and MetS per se was an independent risk factor for microalbuminuria. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.diabres.2014.12.005
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의학전문대학원 > 의학과 > Journal papers
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