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Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity

Title
Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity
Authors
Lee, Hyang WoonArora, JagritiPapademetris, XenophonTokoglu, FuyuzeNegishi, MichiroScheinost, DustinFarooque, PueBlumenfeld, HalSpencer, Dennis D.Constable, R. Todd
Ewha Authors
이향운
SCOPUS Author ID
이향운scopus
Issue Date
2014
Journal Title
NEUROLOGY
ISSN
0028-3878JCR Link1526-632XJCR Link
Citation
vol. 83, no. 24, pp. 2269 - 2277
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Objective:The purpose of this study was to investigate functional connectivity (FC) changes in epileptogenic networks in intractable partial epilepsy obtained from resting-state fMRI by using intrinsic connectivity contrast (ICC), a voxel-based network measure of degree that reflects the number of connections to each voxel.Methods:We measured differences between intrahemispheric- and interhemispheric-ICC (ICCintra-inter) that could reveal localized connectivity abnormalities in epileptogenic zones while more global network changes would be eliminated when subtracting these values. The ICCintra-inter map was compared with the seizure onset zone (SOZ) based on intracranial EEG (icEEG) recordings in 29 patients with at least 1 year of postsurgical follow-up. Two independent reviewers blindly interpreted the icEEG and fMRI data, and the concordance rates were compared for various clinical factors.Results:Concordance between the icEEG SOZ and ICCintra-inter map was observed in 72.4% (21/29) of the patients, which was higher in patients with good surgical outcome, especially in those patients with temporal lobe epilepsy (TLE) or lateral temporal seizure localization. Concordance was also better in the extratemporal lobe epilepsy than the TLE group. In 85.7% (18/21) of the cases, the ICCintra-inter values were negative in the SOZ, indicating decreased FC within the epileptic hemisphere relative to between hemispheres.Conclusions:Assessing alterations in FC using fMRI-ICC map can help localize the SOZ, which has potential as a noninvasive presurgical diagnostic tool to improve surgical outcome. In addition, the method reveals that, in focal epilepsy, both intrahemispheric- and interhemispheric-FC may be altered, in the presence of both regional as well as global network abnormalities.
DOI
10.1212/WNL.0000000000001068
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의학전문대학원 > 의학과 > Journal papers
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