View : 34 Download: 0

Anatomical heterogeneity of Alzheimer disease Based on cortical thickness on MRIs

Title
Anatomical heterogeneity of Alzheimer disease Based on cortical thickness on MRIs
Authors
Noh, YoungJeon, SeunLee, Jong MinSeo, Sang WonKim, Geon HaCho, HannaYe, Byoung SeokYoon, Cindy W.Kim, Hee JinChin, JuheePark, Kee HyungHeilman, Kenneth M.Na, Duk L.
Ewha Authors
김건하
Issue Date
2014
Journal Title
NEUROLOGY
ISSN
0028-3878JCR Link1526-632XJCR Link
Citation
vol. 83, no. 21, pp. 1936 - 1944
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Objective: Because the signs associated with dementia due to Alzheimer disease (AD) can be heterogeneous, the goal of this study was to use 3-dimensional MRI to examine the various patterns of cortical atrophy that can be associated with dementia of AD type, and to investigate whether AD dementia can be categorized into anatomical subtypes. Methods: High-resolution T1-weighted volumetric MRIs were taken of 152 patients in their earlier stages of AD dementia. The images were processed to measure cortical thickness, and hierarchical agglomerative cluster analysis was performed using Ward's clustering linkage. The identified clusters of patients were compared with an age-and sex-matched control group using a general linear model. Results: There were several distinct patterns of cortical atrophy and the number of patterns varied according to the level of cluster analyses. At the 3-cluster level, patients were divided into (1) bilateral medial temporal-dominant atrophy subtype (n = 52, similar to 34.2%), (2) parietal-dominant subtype (n = 28, similar to 18.4%) in which the bilateral parietal lobes, the precuneus, along with bilateral dorsolateral frontal lobes, were atrophic, and (3) diffuse atrophy subtype (n = 72, similar to 47.4%) in which nearly all association cortices revealed atrophy. These 3 subtypes also differed in their demographic and clinical features. Conclusions: This cluster analysis of cortical thickness of the entire brain showed that AD dementia in the earlier stages can be categorized into various anatomical subtypes, with distinct clinical features.
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE