Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 임재향 | * |
dc.date.accessioned | 2016-08-27T04:08:04Z | - |
dc.date.available | 2016-08-27T04:08:04Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 0001-6489 | * |
dc.identifier.issn | 1651-2251 | * |
dc.identifier.other | OAK-12154 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216952 | - |
dc.description.abstract | Conclusion: Bullae of type 1 plasminogen activator inhibitor (PAI-1) knockout (KO) mice showed low levels of inflammation against nontypable Haemophilus influenzae (NTHi) at the early stage of otitis media (OM). However, PAI-1 KO mice fail to terminate inflammation, which may significantly contribute to the development of tympanosclerosis in PAI-1 KO mice. Objective: To investigate the role of PAI-1 in the pathogenesis of OM and subsequent tympanosclerosis. Methods: OM was induced with NTHi in PAI-1 KO and background control C57BL/6 mice. mRNA expression of PAI-1, tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA) was measured in the bullae of C57BL/6 mice. mRNA expression of interleukin (IL)-1 beta, tumor necrosis factor (TNF) alpha, macrophage inflammatory protein (MIP-2), tPA, and uPA in PAI-1 KO and C57BL/6 mice was compared. Histological changes produced by OM were compared at 1, 3, and 7 days after NTHi inoculation. Results: NTHi up-regulated the expression of PAI-1 and tPA in the bullae of C57BL/6 mice, but not uPA. mRNA expression of IL-1 beta, TNF alpha, and MIP-2 was low in PAI-1 KO mice at early time points, but significantly higher at the later stage of OM. Similarly to the gene expression results, histological changes associated with OM were less at days 1 and 3 in PAI-1 KO mice. However, unlike the gradual resolution of OM pathologies in C57BL/6 mice, PAI-1 KO mice showed significant pathological changes of tympanosclerosis. | * |
dc.language | English | * |
dc.publisher | INFORMA HEALTHCARE | * |
dc.subject | Nontypable Haemophilus influenzae | * |
dc.subject | type 1 plasminogen activator inhibitor | * |
dc.subject | inflammation | * |
dc.title | PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 134 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1231 | * |
dc.relation.lastpage | 1238 | * |
dc.relation.journaltitle | ACTA OTO-LARYNGOLOGICA | * |
dc.identifier.doi | 10.3109/00016489.2014.940554 | * |
dc.identifier.wosid | WOS:000345214100004 | * |
dc.author.google | Shin, Seul Gi | * |
dc.author.google | Koh, Seo Hyun | * |
dc.author.google | Woo, Chang-Hoon | * |
dc.author.google | Lim, Jae Hyang | * |
dc.contributor.scopusid | 임재향(7403454262) | * |
dc.date.modifydate | 20240429115530 | * |