Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강덕희 | - |
dc.contributor.author | 최학선 | - |
dc.contributor.author | 유민아 | - |
dc.date.accessioned | 2016-08-27T04:08:58Z | - |
dc.date.available | 2016-08-27T04:08:58Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0023-6837 | - |
dc.identifier.issn | 1530-0307 | - |
dc.identifier.other | OAK-11911 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216905 | - |
dc.description.abstract | Aminoglycoside-induced nephrotoxicity is one of the prevalent causes of acute kidney injury (AKI). Oxidative stress-mediated apoptosis of renal tubular cells is known to be a major mechanism of renal injury. Red ginseng extract (RGE) has been reported to possess antioxidant and immune-modulatory activities. We investigated the effect of RGE on gentamicin (GM)-induced apoptosis and oxidative stress in cultured renal tubular cells and animal model of GM-induced AKI. GM induced the generation of reactive oxygen species (ROS) with an increase in NADPH oxidase (NOX) activity and mitochondrial oxidation in NRK-52E cells that were ameliorated with RGE. GM-induced apoptosis of NRK-52E cells, which was associated with an increased expression of mitochondrial Bax, cytosolic cytochrome c, and cleaved caspase-9 and -3, along with a decrease in bcl-2 expression, was also blocked by RGE. In an animal model of GM-induced AKI, RGE treatment significantly attenuated renal dysfunction, cell apoptosis, and tubular damage. RGE ameliorated ROS production in rats with GM-induced AKI, as demonstrated by an increase in the reduced form of glutathione in renal cortex and a decrease in urinary excretion of 8-hydroxy-2'-deoxyguanosine. Our results suggest that RGE protects the kidney from GM-induced AKI via the mechanism of modulation of oxidative stress. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury | - |
dc.type | Article | - |
dc.relation.issue | 10 | - |
dc.relation.volume | 94 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1147 | - |
dc.relation.lastpage | 1160 | - |
dc.relation.journaltitle | LABORATORY INVESTIGATION | - |
dc.identifier.doi | 10.1038/labinvest.2014.101 | - |
dc.identifier.wosid | WOS:000342481000008 | - |
dc.author.google | Shin, Hyun-Soo | - |
dc.author.google | Yu, Mina | - |
dc.author.google | Kim, Mijin | - |
dc.author.google | Choi, Hack Sun | - |
dc.author.google | Kang, Duk-Hee | - |
dc.contributor.scopusid | 강덕희(17233695600) | - |
dc.contributor.scopusid | 최학선(7404339351) | - |
dc.contributor.scopusid | 유민아(21741685100) | - |
dc.date.modifydate | 20230210140157 | - |