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Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells

Title
Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells
Authors
Pyo, Myoung YunYoon, Soo JeongYu, YeonsilPark, SunyoungJin, Mirim
Ewha Authors
유연실
SCOPUS Author ID
유연실scopus
Issue Date
2014
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN
0916-8451JCR Link1347-6947JCR Link
Citation
vol. 78, no. 6, pp. 1037 - 1043
Keywords
interleukin-4 (IL-4)interleukin-13 (IL-13)cyaniding-3-glucoside (C3G) C3GGATA-binding protein 3 (GATA-3)anti-allergic agent
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Allergic disease is dominated by Th2 immune responses. Interleukin (IL)-4 and IL-13, representative Th2 cytokines, play pivotal roles in the pathogenic activation of the Th2 immune response. In this study, we found that cyanidin-3-glucoside chloride (C3G), an anthocyanin suppressed IL-4 and IL-13 produced in activated EL-4 T cells but not Th1 cytokines including IL-2, interferon-gamma, or IL-12. IL-4 and IL-13 mRNA levels and luciferase activation in cells transiently transfected with IL-4 and IL-13 promoter reporter plasmids were significantly inhibited by C3G, suggesting that suppression might be, at least in part, regulated at the transcriptional level. Data from western blot and reverse transcription-polymerase chain reaction analyses of transcription factors involved in cytokine expression suggested that expression of GATA-3, but not T-bet, was downregulated in the nucleus by C3G. Taken together, our data indicate that C3G may has potential as an anti-allergic agent suppressing Th2 activation by downregulating Th2 cytokines and the GATA3 transcription factor in allergies.
DOI
10.1080/09168451.2014.912115
Appears in Collections:
연구기관 > 의과학연구소 > Journal papers
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