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Cognitive and Psychosocial Effects of Oxcarbazepine Monotherapy in Newly Diagnosed Partial Epilepsy

Title
Cognitive and Psychosocial Effects of Oxcarbazepine Monotherapy in Newly Diagnosed Partial Epilepsy
Authors
Kim, DaeyoungSeo, Ji-HyeJoo, Eun YeonLee, Hyang WoonShin, Won ChulHong, Seung Bong
Ewha Authors
이향운
SCOPUS Author ID
이향운scopus
Issue Date
2014
Journal Title
CLINICAL NEUROPHARMACOLOGY
ISSN
0362-5664JCR Link1537-162XJCR Link
Citation
vol. 37, no. 4, pp. 100 - 107
Keywords
epilepsycognitionpsychosocial difficulties (PSD)oxcarbazepineanticonvulsants
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Objectives: The aim of this study was to assess the effects of oxcarbazepine (OXC) on cognition and psychosocial difficulties in patients with new-onset partial epilepsy. Methods: Cognitive and psychosocial assessments were performed before and after 6 to 12 months of OXC monotherapy in 52 drug-naive patients (25 women; mean age, 31.1 years; SD, 12.1 years). Cognitive functions were evaluated with well-structured and validated tools. Mood, psychological distress, subjective handicap, and quality of life were also evaluated. Differences between baseline and after-treatment evaluation were compared and adjusted for possible confounders such as age, sex, seizure control, duration of epilepsy, assessment interval, and epileptogenic region. Results: Mean assessment interval was 231.8 (range, 182-348) days, and mean (SD) OXC dose at retest was 693.8 (208.9) mg. The OXC was found to have no significant adverse effect on cognition. Furthermore, OXC monotherapy was not found to affect psychosocial difficulties, including psychological distress and subjective handicap. Conclusions: The results suggest that OXC monotherapy could be used to treat newly diagnosed partial epilepsy without adversely affecting cognitive and psychosocial functions.
DOI
10.1097/WNF.0000000000000038
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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