Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-08-27T04:08:52Z | - |
dc.date.available | 2016-08-27T04:08:52Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.issn | 1976-3786 | * |
dc.identifier.other | OAK-11481 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216853 | - |
dc.description.abstract | Echinacea purpurea has been shown to have anti-diabetic activities; for example, it activates peroxisome proliferator-activated receptor gamma (PPAR gamma) and increases insulin-stimulated glucose uptake. Adipogenesis has been used to study the insulin signaling pathway and to screen anti-diabetic compounds. The present study was conducted to investigate the effects of an ethanol extract of E. purpurea (EEEP) and its constituents on the insulin-induced adipocyte differentiation of 3T3-L1 preadipocytes. When adipocyte differentiation was induced with insulin plus 3-isobutyl-1-methylxanthine and dexamethasone, the accumulation of lipid droplets and the cellular triglyceride content were significantly increased by EEEP. The expressions of PPAR gamma and C/EBP alpha in adipocytes treated with EEEP were gradually increased as compared with control cells. Fat accumulation and triglyceride content of adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly increased as compared with control cells. The expressions of PPAR gamma and C/EBP alpha in adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly higher than in control cells. These results suggest EEEP promotes the adipogenesis that is partially induced by insulin and that dodeca-2(E),4(E)-dienoic acid isobutylamide appears to be responsible for EEEP-enhanced adipocyte differentiation. | * |
dc.language | English | * |
dc.publisher | PHARMACEUTICAL SOC KOREA | * |
dc.subject | Echinacea purpurea | * |
dc.subject | 3T3-L1 cells | * |
dc.subject | Adipocyte differentiation | * |
dc.subject | Insulin | * |
dc.subject | Dodeca-2(E),4(E)-dienoic acid isobutylamide | * |
dc.title | Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 803 | * |
dc.relation.lastpage | 812 | * |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | * |
dc.identifier.doi | 10.1007/s12272-013-0251-y | * |
dc.identifier.wosid | WOS:000337038900014 | * |
dc.author.google | Shin, Dong-Mi | * |
dc.author.google | Choi, Kyeong-Mi | * |
dc.author.google | Lee, Youn-Sun | * |
dc.author.google | Kim, Wonkyun | * |
dc.author.google | Shin, Kyong-Oh | * |
dc.author.google | Oh, Seikwan | * |
dc.author.google | Jung, Jae-Chul | * |
dc.author.google | Lee, Mi Kyeong | * |
dc.author.google | Lee, Yong-Moon | * |
dc.author.google | Hong, Jin Tae | * |
dc.author.google | Yun, Yeo-Pyo | * |
dc.author.google | Yoo, Hwan-Soo | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |