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Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells

Title
Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells
Authors
Shin, Dong-MiChoi, Kyeong-MiLee, Youn-SunKim, WonkyunShin, Kyong-OhOh, SeikwanJung, Jae-ChulLee, Mi KyeongLee, Yong-MoonHong, Jin TaeYun, Yeo-PyoYoo, Hwan-Soo
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2014
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link1976-3786JCR Link
Citation
vol. 37, no. 6, pp. 803 - 812
Keywords
Echinacea purpurea3T3-L1 cellsAdipocyte differentiationInsulinDodeca-2(E),4(E)-dienoic acid isobutylamide
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Echinacea purpurea has been shown to have anti-diabetic activities; for example, it activates peroxisome proliferator-activated receptor gamma (PPAR gamma) and increases insulin-stimulated glucose uptake. Adipogenesis has been used to study the insulin signaling pathway and to screen anti-diabetic compounds. The present study was conducted to investigate the effects of an ethanol extract of E. purpurea (EEEP) and its constituents on the insulin-induced adipocyte differentiation of 3T3-L1 preadipocytes. When adipocyte differentiation was induced with insulin plus 3-isobutyl-1-methylxanthine and dexamethasone, the accumulation of lipid droplets and the cellular triglyceride content were significantly increased by EEEP. The expressions of PPAR gamma and C/EBP alpha in adipocytes treated with EEEP were gradually increased as compared with control cells. Fat accumulation and triglyceride content of adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly increased as compared with control cells. The expressions of PPAR gamma and C/EBP alpha in adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantly higher than in control cells. These results suggest EEEP promotes the adipogenesis that is partially induced by insulin and that dodeca-2(E),4(E)-dienoic acid isobutylamide appears to be responsible for EEEP-enhanced adipocyte differentiation.
DOI
10.1007/s12272-013-0251-y
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의학전문대학원 > 의학과 > Journal papers
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