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A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life

Title
A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life
Authors
Shim, BongseokJeong, HyewonLee, SaraHwang, SeheeMoon, ByeongseokStorni, Charlotte
Ewha Authors
정혜원이사라
SCOPUS Author ID
정혜원scopus; 이사라scopus
Issue Date
2014
Journal Title
JOURNAL OF FUNCTIONAL FOODS
ISSN
1756-4646JCR Link
Citation
vol. 8, pp. 111 - 117
Keywords
PumpkinCucurbita pepoSoy germIncontinenceOveractive bladderClinical study
Publisher
ELSEVIER SCIENCE BV
Indexed
SCIE; SCOPUS WOS
Abstract
Overactive bladder (OAB) has become an increasing field of interest. Traditional use indicates that pumpkin seed (Cucurbita pepo L.) may be helpful in combating its symptoms. Additionally, soy isoflavones (Glycine max) are well-documented for hormonal imbalance related indications. The present randomized, double-blind, placebo-controlled study evaluated efficacy and safety of Cucuflavone (containing extracts of pumpkin seed and soy germ) in 120 subjects suffering from OAB. After 12 weeks, subjects taking Cucuflavone experienced a significant reduction versus baseline, in (1) urination frequency, (2) urgency, (3) incontinence frequency, maximum urgency score, (5) nocturnal urination frequency and (6) OAB-symptom scale. The placebo group reached significant differences for (1), (3) and (6). No adverse events or abnormal changes in safety parameters occurred. Thus, the combination of pumpkin seed and soy germ extract can be used as natural alternative to relieve symptoms of OAB and to improve quality of life. (C) 2014 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.jff.2014.03.010
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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