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Immune Enhancing Effects of Echinacea purpurea Root Extract by Reducing Regulatory T Cell Number and Function

Title
Immune Enhancing Effects of Echinacea purpurea Root Extract by Reducing Regulatory T Cell Number and Function
Authors
Kim, Hyung-RanOh, Sei-KwanLim, WoosungLee, Hyeon KookMoon, Byung-InSeoh, Ju-Young
Ewha Authors
서주영문병인오세관이현국임우성
SCOPUS Author ID
서주영scopus; 문병인scopus; 오세관scopus; 이현국scopus; 임우성scopus
Issue Date
2014
Journal Title
NATURAL PRODUCT COMMUNICATIONS
ISSN
1934-578XJCR Link1555-9475JCR Link
Citation
vol. 9, no. 4, pp. 511 - 514
Keywords
Echinacea purpureaImmunomodulationRegulatory T cellFoxP3
Publisher
NATURAL PRODUCTS INC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Echinacea purpurea preparations (EPs) have been traditionally used for the treatment of various infections and also for wound healing. Accumulating evidence suggests their immunostimulatory effects. Regulatory T cells (Tregs) are known to play a key role in immune regulation in vivo. However, there have been no reports so far on the effects of EP on the frequency or function of Tregs in vivo. Therefore, in the present study, we investigated the quantitative and functional changes in Tregs by in vivo administration with EP. The frequencies of CD4(+)FoxP3(+) and CD4(+)CD25(+) Tregs in the spleens of BALB/c mice administered with EP for 3 weeks were investigated by flow cytometry. The suppressive function of CD4(+)CD25(+) Tregs in association with the proliferative activity of CD4(+)CD25(-) effector T cells (Teffs) and the feeder function of CD4(-) antigen-presenting cells (APCs) were analyzed by carboxyfluorescein succinimidyl ester-dilution assay. The results showed a lowered frequency of CD4(+)FoxP3(+) and CD4(+)CD25(+) Tregs and attenuated suppressive function of CD4(+)CD25(+) Tregs, while the feeder function of APCs was enhanced in the EP-administered mice. On the other hand, the proliferative activity of Teffs was not significantly different in the EP-administered mice. The results suggest that decreased number and function of Tregs, in association with the enhanced feeder function of APCs, may contribute to the enhancement of immune function by EP.
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의과대학 > 의학과 > Journal papers
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