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dc.contributor.author정우진-
dc.date.accessioned2016-08-27T04:08:47Z-
dc.date.available2016-08-27T04:08:47Z-
dc.date.issued2014-
dc.identifier.issn0250-7005-
dc.identifier.issn1791-7530-
dc.identifier.otherOAK-11060-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/216812-
dc.description.abstractAim: We aimed to investigate the clinical significance of the activation of Yes-Associated Protein 1 (YAP1), a key downstream effector of Hippo tumor-suppressor pathway, in ovarian cancer. Materials and Methods: A gene expression signature reflecting activation of YAP1 was developed from gene expression data of 267 samples from patients with ovarian cancer. A refined ovarian cancer YAP1 signature was validated in an independent ovarian cancer cohort (n=185). Associations between the YAP1 signature and prognosis were assessed using Kaplan-Meier plots, the log-rank test, and a Cox proportional hazards model. Results: We identified a 612-gene expression signature reflecting YAP1 activation in ovarian cancer. In multivariate analysis, the signature was an independent predictor of overall survival (hazard ratio=1.66; 95% confidence interval=1.1 to 2.53; p=0.01). In subset analysis, the signature identified patients likely to benefit from taxane-based adjuvant chemotherapy. Conclusion: Activation of YAP1 is significantly associated with prognosis and the YAP1 signature can predict response to taxane-based adjuvant chemotherapy in patients with ovarian cancer.-
dc.languageEnglish-
dc.publisherINT INST ANTICANCER RESEARCH-
dc.subjectDNA microarrays-
dc.subjectovarian cancer-
dc.subjectprognosis-
dc.subjecttaxane-
dc.subjectYAP1-
dc.titleActivation of YAP1 Is Associated with Poor Prognosis and Response to Taxanes in Ovarian Cancer-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume34-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage811-
dc.relation.lastpage817-
dc.relation.journaltitleANTICANCER RESEARCH-
dc.identifier.wosidWOS:000331497200035-
dc.author.googleJeong, Woojin-
dc.author.googleKim, Sang-Bae-
dc.author.googleSohn, Bo Hwa-
dc.author.googlePark, Yun-Yong-
dc.author.googlePark, Bun Sung-
dc.author.googleKim, Sang Cheol-
dc.author.googleKim, Sung Soo-
dc.author.googleJohnson, Randy L.-
dc.author.googleBirrer, Michael-
dc.author.googleBowtell, David S. L.-
dc.author.googleMills, Gordon B.-
dc.author.googleSood, Anil-
dc.author.googleLee, Ju-Seog-
dc.contributor.scopusid정우진(35914322500)-
dc.date.modifydate20190901081003-
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자연과학대학 > 생명과학전공 > Journal papers
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