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Activation of YAP1 Is Associated with Poor Prognosis and Response to Taxanes in Ovarian Cancer

Title
Activation of YAP1 Is Associated with Poor Prognosis and Response to Taxanes in Ovarian Cancer
Authors
Jeong, WoojinKim, Sang-BaeSohn, Bo HwaPark, Yun-YongPark, Bun SungKim, Sang CheolKim, Sung SooJohnson, Randy L.Birrer, MichaelBowtell, David S. L.Mills, Gordon B.Sood, AnilLee, Ju-Seog
Ewha Authors
정우진
SCOPUS Author ID
정우진scopus
Issue Date
2014
Journal Title
ANTICANCER RESEARCH
ISSN
0250-7005JCR Link1791-7530JCR Link
Citation
vol. 34, no. 2, pp. 811 - 817
Keywords
DNA microarraysovarian cancerprognosistaxaneYAP1
Publisher
INT INST ANTICANCER RESEARCH
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Aim: We aimed to investigate the clinical significance of the activation of Yes-Associated Protein 1 (YAP1), a key downstream effector of Hippo tumor-suppressor pathway, in ovarian cancer. Materials and Methods: A gene expression signature reflecting activation of YAP1 was developed from gene expression data of 267 samples from patients with ovarian cancer. A refined ovarian cancer YAP1 signature was validated in an independent ovarian cancer cohort (n=185). Associations between the YAP1 signature and prognosis were assessed using Kaplan-Meier plots, the log-rank test, and a Cox proportional hazards model. Results: We identified a 612-gene expression signature reflecting YAP1 activation in ovarian cancer. In multivariate analysis, the signature was an independent predictor of overall survival (hazard ratio=1.66; 95% confidence interval=1.1 to 2.53; p=0.01). In subset analysis, the signature identified patients likely to benefit from taxane-based adjuvant chemotherapy. Conclusion: Activation of YAP1 is significantly associated with prognosis and the YAP1 signature can predict response to taxane-based adjuvant chemotherapy in patients with ovarian cancer.
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자연과학대학 > 생명과학전공 > Journal papers
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