Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강상원 | * |
dc.contributor.author | 김완규 | * |
dc.date.accessioned | 2016-08-27T04:08:45Z | - |
dc.date.available | 2016-08-27T04:08:45Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 2041-1723 | * |
dc.identifier.other | OAK-10915 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216796 | - |
dc.description.abstract | MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-sensitive microRNAs in atherosclerosis is still unclear. Here we identify miRNA-712 (miR-712) as a mechanosensitive miRNA upregulated by disturbed flow (d-flow) in endothelial cells, in vitro and in vivo. We also show that miR-712 is derived from an unexpected source, pre-ribosomal RNA, in an exoribonuclease-dependent but DiGeorge syndrome critical region 8 (DGCR8)-independent manner, suggesting that it is an atypical miRNA. Mechanistically, d-flow-induced miR-712 downregulates tissue inhibitor of metalloproteinase 3 (TIMP3) expression, which in turn activates the downstream matrix metalloproteinases (MMPs) and a disintegrin and metalloproteases (ADAMs) and stimulate pro-atherogenic responses, endothelial inflammation and permeability. Furthermore, silencing miR-712 by anti-miR-712 rescues TIMP3 expression and prevents atherosclerosis in murine models of atherosclerosis. Finally, we report that human miR-205 shares the same 'seed sequence' as murine-specific miR-712 and also targets TIMP3 in a flow-dependent manner. Targeting these mechanosensitive 'athero-miRs' may provide a new treatment paradigm in atherosclerosis. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis | * |
dc.type | Article | * |
dc.relation.volume | 4 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NATURE COMMUNICATIONS | * |
dc.identifier.doi | 10.1038/ncomms4000 | * |
dc.identifier.wosid | WOS:000329398500001 | * |
dc.author.google | Son, Dong Ju | * |
dc.author.google | Kumar, Sandeep | * |
dc.author.google | Takabe, Wakako | * |
dc.author.google | Kim, Chan Woo | * |
dc.author.google | Ni, Chih-Wen | * |
dc.author.google | Alberts-Grill, Noah | * |
dc.author.google | Jang, In-Hwan | * |
dc.author.google | Kim, Sangok | * |
dc.author.google | Kim, Wankyu | * |
dc.author.google | Kang, Sang Won | * |
dc.author.google | Baker, Andrew H. | * |
dc.author.google | Seo, Jai Woong | * |
dc.author.google | Ferrara, Katherine W. | * |
dc.author.google | Jo, Hanjoong | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 김완규(25627654100) | * |
dc.date.modifydate | 20240130091819 | * |