Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2016-08-27T02:08:33Z | - |
dc.date.available | 2016-08-27T02:08:33Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1017-7825 | * |
dc.identifier.other | OAK-9940 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216718 | - |
dc.description.abstract | Monocyte chemotactic protein-3 (MCP-3), a chemokine that is in a superfamily of structurally related small chemotactic cytokines involved in leukocyte trafficking, is regarded as a key factor in atherogenesis. In this study, we examined the changes in atherogenic parameters including hepatic lipid accumulation and oxidative balance in MCP-3-overexpressing transgenic mice (MCP-3 mice) under atherogenic conditions. To induce an extreme atherogenic condition, mice were fed a high-fat, high-cholesterol (HFHC) diet for 12 weeks. The body weight and food intake were not changed by MCP-3 overexpression in the aorta. On a HFHC diet, the MCP-3 mice had higher plasma levels of total cholesterol and a higher atherogenic index compared with wild-type mice, although there were no differences in the plasma HDL-cholesterol and triglyceride levels. Furthermore, an increase in lipid accumulation was observed in the aortas as well as the livers of the HFHC diet-fed MCP-3 mice compared with wild-type mice. The activities of antioxidant enzymes increased in the livers of the HFHC diet-fed MCP-3 mice, whereas supplementation with antioxidants, naringin and hesperidin, reversed the activities of the hepatic antioxidant enzymes in HFHC diet-fed MCP-3 mice, indicating that there might be more oxidative damage to the tissues in the HFHC diet-fed MCP-3 mice leading to progression towards atherosclerosis and hepatic steatosis. Microarray analyses of the aorta revealed atherosclerosis-, PPARs-, lipoprotein receptor, and apolipoprotein-related genes that were affected by the HFHC diet in MCP-3 mice. These findings suggest that aortic MCP-3 overexpression may contribute to the development of atherosclerosis and hepatic steatosis under atherogenic conditions. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC MICROBIOLOGY & | * |
dc.publisher | BIOTECHNOLOGY | * |
dc.subject | Monocyte chemotactic protein-3 (MCP-3) | * |
dc.subject | atherogenesis | * |
dc.subject | transgenic mice | * |
dc.title | Functions of Monocyte Chemotactic Protein-3 in Transgenic Mice Fed a High-Fat, High-Cholesterol Diet | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 405 | * |
dc.relation.lastpage | 413 | * |
dc.relation.journaltitle | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | * |
dc.identifier.doi | 10.4014/jmb.1210.10057 | * |
dc.identifier.wosid | WOS:000316919500017 | * |
dc.author.google | An, So Jung | * |
dc.author.google | Jung, Un Ju | * |
dc.author.google | Choi, Myung-Sook | * |
dc.author.google | Chae, Chan Kyu | * |
dc.author.google | Oh, Goo Taek | * |
dc.author.google | Park, Yong Bok | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |