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Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study

Title
Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study
Authors
Choi, Seong HyeKim, SangYunHan, Seol-HeuiNa, Duk L.Kim, Doh-KwanCheong, Hae-KwanLee, Jae-HongKim, Seong YoonHong, Chang HyungMoon, So YoungKwon, Jay C.Kim, Jung EunJeong, Jee H.Na, Hae RiCha, Kyung RyeolSeo, Sang WonShim, Yong S.Lee, Jun-YoungPark, Kyung Won
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2012
Journal Title
NEUROLOGICAL SCIENCES
ISSN
1590-1874JCR Link
Citation
vol. 33, no. 4, pp. 839 - 846
Keywords
Subcortical ischemic vascular dementiaNeurologic signExecutive dysfunctionCognitionSmall-vessel diseaseWhite matter changes
Publisher
SPRINGER
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from multiple nationwide hospitals. The patients' neurologic signs were evaluated using the Focal Neurologic Sign Score (FNSS). The FNSS scores did not correlate with the composite neuropsychology scores and Korean Mini-Mental State Examination scores. The FNSS scores correlated with the letter fluency and Rey-Osterrieth Complex Figure (ROCF) copy scores. Using a multivariate regression analysis controlled for age, sex, and educational level, the FNSS scores had a significant relationship with the letter fluency test scores (R (2) = 0.08, beta = -2.28, p = 0.02) and ROCF copy scores (R (2) = 0.08, beta = -0.42, p = 0.03). These findings suggest that the neurologic signs in patients with SIVD do not correlate with global cognitive functions; however, these signs do correlate with executive dysfunction in these patients.
DOI
10.1007/s10072-011-0845-4
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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