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The Culture Filtrates from Bacillus subtilis natto Lowers Blood Pressure via Renin-angiotensin System in Spontaneously Hypertensive Rats Fed with a High-cholesterol Diet

Title
The Culture Filtrates from Bacillus subtilis natto Lowers Blood Pressure via Renin-angiotensin System in Spontaneously Hypertensive Rats Fed with a High-cholesterol Diet
Authors
Kim, Yeon KyoungKim, Sang MiKim, Ji YeonKwon, Oran
Ewha Authors
권오란김지연
SCOPUS Author ID
권오란scopus
Issue Date
2011
Journal Title
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
ISSN
1738-2203JCR Link
Citation
vol. 54, no. 6, pp. 959 - 965
Keywords
blood pressurefibrinolytic activitynattokinaserenin-angiotensin systemspontaneously hypertensive rat
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Antihypertensive effect of the culture filtrates from Bacillus subtilis natto (CFB) associated with renin-angiotensin system (RAS) as well as fibrinolytic and anti-thrombotic activity was examined. By using the spontaneously hypertensive rats fed with a high-cholesterol diet (0.5% cholesterol and 0.5% cholic acid), biomarkers related to the RAS were measured after 11 week-administration of CFB in the diet at 1 or 2% levels. Systolic blood pressure was significantly attenuated by CFB at both levels. Plasma renin activity was significantly suppressed by CFB, and protein expression of renin in kidney also showed tendency of decrease by administration of CFB, although not statistically significant. Renal angiotensin II concentrations were decreased, whereas plasma angiotensin II concentrations showed no differences among groups. Whole blood clotting and euglobulin clot lysis time showed insignificant changes, but downward tendencies by CFB supplementation. Although further study is necessary to clearly elucidate the related mechanism, taken together, these findings support the hypothesis that CFB could be potentially used as dietary supplement to suppress hypertension.
DOI
10.3839/jksabc.2011.144
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신산업융합대학 > 식품영양학과 > Journal papers
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