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Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts

Title
Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts
Authors
Song, Kyu ChoonChang, Tong-ShinLee, HyejinKim, JinheePark, Jeong HillHwang, Gwi Seo
Ewha Authors
창동신
SCOPUS Author ID
창동신scopus
Issue Date
2012
Journal Title
JOURNAL OF GINSENG RESEARCH
ISSN
1226-8453JCR Link
Citation
vol. 36, no. 1, pp. 61 - 67
Keywords
Panax ginsengSun ginseng (SE)Type I collagenMatrix metalloproteinase-1Human skin fibroblasts
Publisher
KOREAN SOC GINSENG
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast.
DOI
10.5142/jgr.2012.36.1.61
Appears in Collections:
약학대학 > 약학과 > Journal papers
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