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Simple synthesis and biological evaluation of flocoumafen and its structural isomers

Title
Simple synthesis and biological evaluation of flocoumafen and its structural isomers
Authors
Jung, Jae-ChulJang, SoyongOh, SeikwanPark, Oee-Sook
Ewha Authors
오세관정재철
SCOPUS Author ID
오세관scopus
Issue Date
2010
Journal Title
JOURNAL OF CHEMICAL SCIENCES
ISSN
0253-4134JCR Link
Citation
vol. 122, no. 6, pp. 833 - 838
Keywords
Flocoumafenintramolecular ring cyclizationcoupling reactionNO-generationneurotoxicity
Publisher
INDIAN ACAD SCIENCES
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 A mu M in vitro, while no significant effect for neurotoxicity in cultured cortical neurons.
DOI
10.1007/s12039-010-0071-2
Appears in Collections:
의과대학 > 의학과 > Journal papers
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