View : 20 Download: 0

Osseointegration of Anodized Titanium Implants Coated with Poly(lactide-co-glycolide)/Basic Fibroblast Growth Factor by Electrospray

Title
Osseointegration of Anodized Titanium Implants Coated with Poly(lactide-co-glycolide)/Basic Fibroblast Growth Factor by Electrospray
Authors
Lee, Su YoungKoak, Jai YoungHeo, Seong JooKim, Seong KyunLee, Seung JinNam, Seung Yeon
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2010
Journal Title
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
ISSN
0882-2786JCR Link
Citation
vol. 25, no. 2, pp. 315 - 320
Keywords
anodized titaniumelectrosprayfibroblast growth factorhistomorphometric analysispoly(lactide-co-glycolide)
Publisher
QUINTESSENCE PUBLISHING CO INC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Purpose: The purpose of this study was to evaluate the effect of basic fibroblast growth factor (bFGF) in combination with a biodegradable polymer coated onto titanium implants. The implants were inserted in rabbit tibiae, and bone growth was examined by histomorphometric analysis. Materials and Methods: Forty-eight threaded anodized implants were inserted into the tibiae of 12 rabbits. After 12 weeks of healing, an evaluation was made by light microscopy and computerized image analysis. A total of 56 anodized titanium implants were prepared as follows: group 1 was anodized under 300 V; group 2 was anodized then coated with 0.02 mL poly(lactide-co-glycolide) (PLGA) nanoparticles; group 3 was anodized then coated with 0.02 mL PLGA/bFGF nanoparticles (10 ng bFGF); and group 4 was anodized then coated with 0.2 mL PLGA/bFGF nanoparticles (100 ng bFGF). Results: Nanosized particles were observed on the coated implant surfaces. The mean diameter of the nanoparticles was 268.6 +/- 93.2 nm. The mean boneto-implant contact (BIC) percentage in group 4 (44.7%) was significantly greater than that seen in groups 1 (31.4%) and 2 (33.6%) (P < .05). Conclusions: The results of this preliminary study show that coating a titanium implant with PLGA incorporated with bFGF by electrospray may stimulate bone formation adjacent to the surface of an implant inserted in bone. INT J ORAL MAXILLOFAC IMPLANTS 2010; 25: 315-320
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE