View : 27 Download: 5

Interaction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weight

Title
Interaction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weight
Authors
Lee, Bo-EunHong, Yun-ChulPark, HyesookHa, MinaKoo, Bon SangChang, NamsooRoh, Young-ManKim, Boong-NyunKim, Young-JuKim, Byung-MiJo, Seong-JoonHa, Eun-Hee
Ewha Authors
하은희장남수김영주박혜숙이보은김병미
SCOPUS Author ID
하은희scopus; 장남수scopus; 김영주scopus; 박혜숙scopus; 김병미scopus
Issue Date
2010
Journal Title
ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN
0091-6765JCR Link
Citation
vol. 118, no. 3, pp. 437 - 442
Keywords
birth weightGSTM1GSTT1mercurypolymorphismpregnancy
Publisher
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BACKGROUND: Mercury (Hg) is toxic to both the reproductive and nervous systems. In addition, glutathione S-transferases (GSTs), which conjugate glutathione to a variety of electrophilic compounds, are involved in the detoxification of Hg. OBJECTIVE: In this study we examined the association between prenatal exposure to Hg and birth weight as well as the influence of GST polymorphisms. METHODS: The total Hg concentration in maternal and cord blood was measured from 417 Korean women and newborns in the Mothers and Children's Environmental Health study from 2006 to 2008. Information on birth weight was collected from the patients' medical records. The genotyping of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms was carried out using polymerase chain reaction. Regression analysis was performed to determine the association between the blood Hg concentration and birth weight in mothers with GSTM1 and GSTT1 polymorphisms. RESULTS: The geometric mean levels of Hg in the maternal blood during late pregnancy and in cord blood were 3.30 mu g/L and 5.53 mu g/L, respectively. For mothers with the GSTT1 null genotype, elevated Hg levels in maternal blood during late pregnancy were associated with an increased risk of lower birth weight. For mothers with both GSTM1 and GSTT1 null genotype, both maternal and cord blood Hg levels were associated with lower birth weight. CONCLUSIONS: This study suggests that the interactions of Hg with GSTM1 and GSTT1 polymorphisms play a role in reducing birth weight.
DOI
10.1289/ehp.0900731
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
Interaction between GSTM1 GSTT1 Polymorphism and Blood Mercury on Birth Weight.pdf(955.47 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE