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Assessment of the rewarding effects of dimenhydrinate using the conditioned place preference paradigm in mice

Title
Assessment of the rewarding effects of dimenhydrinate using the conditioned place preference paradigm in mice
Authors
Nguyen, Thi-LienYou, In-JeeOh, SeikwanYang, Chae HaLee, Seok-YongJang, Choon-Gon
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2010
Journal Title
NEUROSCIENCE LETTERS
ISSN
0304-3940JCR Link
Citation
vol. 471, no. 1, pp. 38 - 42
Keywords
DimenhydrinateDiphenhydramine8-ChlorotheophyllineCocaineCPP
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Dimenhydrinate (DIM) is an over-the-counter antihistamine consisting of diphenhydramine (DIP) and 8-chlorotheophylline (CTP). Medical use of DIM is for prevention of nausea and motion sickness. Recently, it has been reported that DIM may be used alone or in combination with other drugs for recreational purposes due to its euphoric and hallucinogenic effects. To investigate the putatively rewarding properties of DIM and its constituents DIP and CTP, we used a conditioned place preference (CPP) test in mice. DIM significantly induced CPP at a dose of 30 mg/kg. Neither DIP (3, 10, and 30 mg/kg) nor CTP (3, 10, and 30 mg/kg) alone induced CPP. Because neither DIP nor CTP resulted in CPP, the rewarding property of DIM appears to be caused by the sum of the effects of its constituents. In addition, low doses of DIM (3 mg/kg), co-administered with low doses of cocaine (7.5 mg/kg), significantly induced CPP, while neither low-dose DIM (3 mg/kg) nor low-dose cocaine (7.5 mg/kg) administered separately induced CPP. This result suggests the liability of DIM use in combination with other abused drugs to create a stronger effect, (C) 2010 Elsevier Ireland Ltd. All rights reserved
DOI
10.1016/j.neulet.2010.01.005
Appears in Collections:
의과대학 > 의학과 > Journal papers
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