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Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha 2

Title
Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha 2
Authors
Choi, SojoongKim, YeonheePark, HaeinHan, Inn-OcChung, EunkyungLee, Sung-YulKim, Yong-BaeLee, Jung WeonOh, Eok-SooYi, Jae Youn
Ewha Authors
오억수
SCOPUS Author ID
오억수scopus
Issue Date
2009
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN
0006-291XJCR Link
Citation
vol. 384, no. 2, pp. 231 - 235
Keywords
Syndecan-2Integrin alpha 2AdhesionMigrationInvasionColon cancer cell
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Syndecan-2, a transmembrane heparan Sulfate proteoglycan, is known to serve as an adhesion receptor, but details of the regulatory mechanism governing syndecan-2 cell adhesion and migration remain unclear. Here, we examined this regulatory mechanism, showing that overexpression of syndecan-2 enhanced collagen adhesion, cell migration and invasion of normal rat intestinal epithelial cells (RIE1), and increased integrin of alpha 2 expression levels. Interestingly, RIE1 cells transfected with either syndecan-2 or integrin of alpha 2 showed similar adhesion and migration patterns, and a function-blocking anti-integrin alpha 2 antibody abolished syndecan-2-mediated adhesion and migration. Consistent with these findings, transfection of integrin alpha 2 siRNA diminished syndecan-2-induced cell migration in HCT116 human colon cancer cells. Taken together. these results demonstrate a novel cooperation between syndecan-2 and integrin alpha 2 beta 1 in adhesion-mediated cell migration and invasion. This interactive dynamic might be a possible mechanism Underlying the tumorigenic activities of colon cancer cells. (C) 2009 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2009.04.093
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자연과학대학 > 생명과학전공 > Journal papers
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