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Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma

Title
Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma
Authors
Song, Hyun JooShim, Ki-NamJoo, Yang-HeeKim, Seong-EunJung, Sung-AeYoo, Kwon
Ewha Authors
유권정성애심기남김성은
SCOPUS Author ID
유권scopus; 정성애scopus; 심기남scopus; 김성은scopus
Issue Date
2008
Journal Title
GUT AND LIVER
ISSN
1976-2283JCR Link
Citation
vol. 2, no. 2, pp. 119 - 125
Keywords
Runx3 proteinGastric cancersMethylation
Publisher
EDITORIAL OFFICE GUT & LIVER
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Background/Aims: RUNX3 (PEBP2 alpha C/CBFA3/AML2) is a novel tumor suppressor gene in the human gastric carcinoma. The aims of this study were to determine the methylation of RUNX3 promoter and the association between RUNX3 methylation and the clinicopathological characteristics of patients with gastric carcinoma. Methods: Seventy-nine patients with gastric carcinoma were studied prospectively from April 2005 to May 2007. The methylations of RUNX3 promoter on the gastric carcinoma specimens and the corresponding nonneoplastic mucosa were evaluated by methylation-specific polymerase chain reaction. Results: Comparison of the results with the clinicopathological characteristics identified RUNX3 monoallelic methylation in 32.9% (26/79) of the gastric carcinoma patients and in 11.4% (9/79) of those with nonneoplastic mucosa (p=0.053). The monoallelic methylated gastric carcinoma specimens predominantly consisted of well- and moderately differentiated carcinomas (44.7%), with the unmethylated group constituting 22.0% of them (p=0.031). Among the 48 patients (60.8%) who underwent gastrectomy, there was no correlation between the two groups with regard to Lauren's classification (p=0.235), depth of invasion (p=0.990), nodal status (p=0.601), stage (p=0.900), lymphatic invasion (p=0.537), and vascular invasion (p=0.815). Conclusions: Methylation of the tumor suppressor gene RUNX3 might be one of the mechanisms involved in the pathogenesis of gastric carcinoma. (Gut and Liver 2008;2:119-125)
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의학전문대학원 > 의학과 > Journal papers
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