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In situ Gel Forming Stereocomplex Composed of Four-Arm PEG-PDLA and PEG-PLLA Block Copolymers

Title
In situ Gel Forming Stereocomplex Composed of Four-Arm PEG-PDLA and PEG-PLLA Block Copolymers
Authors
Jun, Yeo JinPark, Kyung MinJoung, Yoon KiPark, Ki DongLee, Seung Jin
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2008
Journal Title
MACROMOLECULAR RESEARCH
ISSN
1598-5032JCR Link
Citation
vol. 16, no. 8, pp. 704 - 710
Keywords
injectable hydrogelin situ hydrogelationstereocomplex formation4-arm PEG-PLA enantiomers
Publisher
POLYMER SOC KOREA
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Injectable hydrogels are quite promising materials due to their potential to minimize invasive implantation and this provides versatile fitness irrespective of the damaged regions and facilitates the incorporation of bioactive agents or cells. In situ gel formation through stereocornplex formation is a promising candidate for injectable hydrogels. In this paper, a new series of enantiomeric, four-arm, PEG-PLA block copolymers and their stereocomplexed hydrogels were prepared by bulk ring-opening polymerization of D-lactide and L-lactide, respectively, with stannous octoate as a catalyst. The prepared polymers were characterized by (1)H nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FT IR) spectroscopy, get permeation chromatography (GPC) and thermal gravitational analysis (TGA), confirming the tailored structure and chain lengths. The swelling and degradation behavior of the hydrogels formed from a selected copolymer series were observed in different concentrations. The degradation rate decreased with increasing polymer content in the Solution. The rheological behavior indicated that the prepared hydrogel underwent in situ gelation and had favorable mechanical strength. In addition, its feasibility as,in injectable scaffold was evaluated using a media dependence test for cell Culture. A Tris solution was more favorable for in situ gel formation than PBS and DMEM Solutions were. These results demonstrated the in situ formation of hydrogel through the construction of a stereocomplex with enantiomeric, 4-arm, PEG-PLA copolymers. Overall, enaritiomeric, 4-arm, PEG-PLA copolymers are a new species of stereocomplexed hydrogels that arc suitable for further research into injectable hydrogels.
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약학대학 > 약학과 > Journal papers
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