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dc.contributor.author오억수-
dc.date.accessioned2016-08-27T02:08:51Z-
dc.date.available2016-08-27T02:08:51Z-
dc.date.issued2008-
dc.identifier.issn0253-2964-
dc.identifier.otherOAK-4880-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/216249-
dc.description.abstractSyndecan-3 is a cell-surface heparan sulfate proteoglycan, which performs a variety of functions during cell adhension process. It is also a coreceptor for growth factor, mediating cell-cell and cell-matrix interaction. Syndecan-3 contains a cytoplasmic domain potentially associated with the cytoskeleton. Syndecan-3 is specifically expressed in neuron cell and has related to neuron cell differentiation and development of actin filament in cell migration. Syndecans each have a unique, central, and variable (V) region in their cytoplasmic domains. And that region of syndecan-3 may modulate the interactions of the conserved Cl regions of the cytoplasmic domains by tyrosine phosphorylation. Cytoplasmic domain of syndecan-3 has been synthesized for NMR structural studies. The solution structure of syndecan-3 cytoplasmic domain has been determined by two-dimensional NMR spectroscopy and simulated-annealing calculation. The cytoplasmic domain of the syndecan proteins has a tendency to form a dimmer conformation with a central cavity, however, that of syndecan-3 demonstrated a monomer conformation with a flexible region near C-terminus. The structural information might add knowledge about the structure-function relationships among syndecan proteins.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subjectsyndecan-3-
dc.subjectproteoglycan-
dc.subjectNMR-
dc.titleSolution structure of the cytoplasmic domain of syndecan-3 by two-dimensional NMR spectroscopy-
dc.typeArticle-
dc.relation.issue5-
dc.relation.volume29-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage1013-
dc.relation.lastpage1017-
dc.relation.journaltitleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.identifier.wosidWOS:000256784600023-
dc.identifier.scopusid2-s2.0-45149104063-
dc.author.googleYeo, In Young-
dc.author.googleKoo, Bonkyung-
dc.author.googleOh, Eok-soo-
dc.author.googleHan, Inn-Oc-
dc.author.googleLee, Weontae-
dc.contributor.scopusid오억수(7101967153)-
dc.date.modifydate20190901081003-
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자연과학대학 > 생명과학전공 > Journal papers
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