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dc.contributor.author오구택*
dc.date.accessioned2016-08-27T02:08:50Z-
dc.date.available2016-08-27T02:08:50Z-
dc.date.issued2008*
dc.identifier.issn1017-7825*
dc.identifier.otherOAK-4771*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/216241-
dc.description.abstractThe inhibitory effects of 5,6,3',5'-tetramethoxy 7,4'-hydroxyflavone (labeled as p7F) were elucidated on the productions of proinflammatory cytokines as well as inflammatory mediators in human synovial fibroblasts and macrophage cells. p7F inhibited IL-1 beta or TNF-alpha induced expressions of inflammatory mediators (ICAM-1, COX-2, and iNOS). p7F also inhibited LPS-induced productions of nitric oxide and prostaglandin E, in RAW 264.7 cells. In order to investigate whether p7F would inhibit IL-1 signaling, p7F was added to the D10S Th2 cell fine (which is responsive to only IL-1 beta and thus proliferates), revealing that p7F inhibited IL-1 beta-induced proliferation of D10S Th2 cells in a dose-response manner. A flow cytometric analysis revealed that p7F reduced the intracellular level of free radical oxygen species in RAW 264.7 cells treated with hydrogen peroxide. p7F inhibited 1 kappa B degradation and NF-kappa B activation in macrophage cells treated with LPS, supporting that p7F could inhibit signaling mediated via toll-like receptor. Taken together, p7F has inhibitory effects on LPS-induced productions of inflammatory mediators on human synovial fibroblasts and macrophage cells and thus has the potential to be an anti-inflammatory agent for inhibiting inflammatory responses.*
dc.languageEnglish*
dc.publisherKOREAN SOC MICROBIOLOGY &amp*
dc.publisherBIOTECHNOLOGY*
dc.subjectanti-inflammatory agent*
dc.subjectflavone*
dc.subjectsynovial fibroblasts*
dc.subjectinflammatory mediators*
dc.subjectproinflammatory cytokines*
dc.titleEffects of a tetramethoxyhydroxyflavone on the expression of inflammatory mediators in LPS-treated human synovial fibroblast and macrophage cells*
dc.typeArticle*
dc.relation.issue4*
dc.relation.volume18*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.indexKCI*
dc.relation.startpage686*
dc.relation.lastpage694*
dc.relation.journaltitleJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY*
dc.identifier.wosidWOS:000255424600012*
dc.identifier.scopusid2-s2.0-48649104803*
dc.author.googleDoyoung, Yoon*
dc.author.googleCho, Minchull*
dc.author.googleKim, Jung-Hee*
dc.author.googleKim, Eun-Jin*
dc.author.googleKang, Jeong-Woo*
dc.author.googleSeo, Eun-Hee*
dc.author.googleShim, Jung-Hyun*
dc.author.googleKim, Soo-Hyun*
dc.author.googleLee, Hee-Gu*
dc.author.googleOh, Goo-Taeg*
dc.author.googleHong, Jin-Tae*
dc.author.googlePark, Joowon*
dc.author.googleKim, Jong-Wan*
dc.contributor.scopusid오구택(7007056663)*
dc.date.modifydate20240123094756*
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자연과학대학 > 생명과학전공 > Journal papers
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