Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2016-08-27T02:08:50Z | - |
dc.date.available | 2016-08-27T02:08:50Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 1017-7825 | * |
dc.identifier.other | OAK-4771 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216241 | - |
dc.description.abstract | The inhibitory effects of 5,6,3',5'-tetramethoxy 7,4'-hydroxyflavone (labeled as p7F) were elucidated on the productions of proinflammatory cytokines as well as inflammatory mediators in human synovial fibroblasts and macrophage cells. p7F inhibited IL-1 beta or TNF-alpha induced expressions of inflammatory mediators (ICAM-1, COX-2, and iNOS). p7F also inhibited LPS-induced productions of nitric oxide and prostaglandin E, in RAW 264.7 cells. In order to investigate whether p7F would inhibit IL-1 signaling, p7F was added to the D10S Th2 cell fine (which is responsive to only IL-1 beta and thus proliferates), revealing that p7F inhibited IL-1 beta-induced proliferation of D10S Th2 cells in a dose-response manner. A flow cytometric analysis revealed that p7F reduced the intracellular level of free radical oxygen species in RAW 264.7 cells treated with hydrogen peroxide. p7F inhibited 1 kappa B degradation and NF-kappa B activation in macrophage cells treated with LPS, supporting that p7F could inhibit signaling mediated via toll-like receptor. Taken together, p7F has inhibitory effects on LPS-induced productions of inflammatory mediators on human synovial fibroblasts and macrophage cells and thus has the potential to be an anti-inflammatory agent for inhibiting inflammatory responses. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC MICROBIOLOGY & | * |
dc.publisher | BIOTECHNOLOGY | * |
dc.subject | anti-inflammatory agent | * |
dc.subject | flavone | * |
dc.subject | synovial fibroblasts | * |
dc.subject | inflammatory mediators | * |
dc.subject | proinflammatory cytokines | * |
dc.title | Effects of a tetramethoxyhydroxyflavone on the expression of inflammatory mediators in LPS-treated human synovial fibroblast and macrophage cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 686 | * |
dc.relation.lastpage | 694 | * |
dc.relation.journaltitle | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | * |
dc.identifier.wosid | WOS:000255424600012 | * |
dc.identifier.scopusid | 2-s2.0-48649104803 | * |
dc.author.google | Doyoung, Yoon | * |
dc.author.google | Cho, Minchull | * |
dc.author.google | Kim, Jung-Hee | * |
dc.author.google | Kim, Eun-Jin | * |
dc.author.google | Kang, Jeong-Woo | * |
dc.author.google | Seo, Eun-Hee | * |
dc.author.google | Shim, Jung-Hyun | * |
dc.author.google | Kim, Soo-Hyun | * |
dc.author.google | Lee, Hee-Gu | * |
dc.author.google | Oh, Goo-Taeg | * |
dc.author.google | Hong, Jin-Tae | * |
dc.author.google | Park, Joowon | * |
dc.author.google | Kim, Jong-Wan | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |